Hyperpolarization‐activated currents in presynaptic terminals of mouse cerebellar basket cells
, 2000 Andrew P. Southan +3 more
openalex +1 more source
Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies
Movement Disorders, EarlyView.Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley +1 more source
SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. [PDF]
Nat Commun, 2019 Andres-Alonso M +22 more
europepmc +1 more source
Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Focused ultrasound is rapidly emerging as a novel technology for the development of symptomatic therapies and supporting disease‐modifying treatments for Parkinson's disease (PD). At the forefront of this development is thermoablation using high‐intensity focused ultrasound, an incisionless treatment that has been extensively tested in ...
Rikke Hahn Kofoed +7 more
wiley +1 more source
Presynaptic Depression in Phasic Motor Nerve Terminals and Influence of 5-HT on Vesicle Dynamics [PDF]
, 2008 Andrew F.M. Johnstone +2 more
openalex +1 more source
Acute Functional Adaptations in Isolated Presynaptic Terminals Unveil Synaptosomal Learning and Memory. [PDF]
Int J Mol Sci, 2019 Pittaluga A.
europepmc +1 more source
Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs [PDF]
, 2009 Hui Zhang +11 more
openalex +1 more source
Spatiotemporal calcium-dynamics in presynaptic terminals
, 2005 This thesis deals with a newly-developed model for the spatiotemporal calcium dynamics within presynaptic terminals. The model is based on single-protein kinetics and has been used to successfully describe different neuron types such as pyramidal neurons in the rat neocortex and the Calyx of Held of neurons from the rat brainstem.
openaire +1 more source
In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease
Movement Disorders, EarlyView.Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale +11 more
wiley +1 more source