Results 91 to 100 of about 2,392 (196)

The role of preclinical SPECT in oncological and neurological research in combination with either CT or MRI [PDF]

, 2014
Preclinical imaging with SPECT combined with CT or MRI is used more and more frequently and has proven to be very useful in translational research. In this article, an overview of current preclinical research applications and trends of SPECT combined ...
Freek J. Beekman, Jan Booij, Marion de Jong, Monique R. Bernsen, Pieter E. B. Vaissier, Roel Van Holen   +5 more
core   +1 more source

Nano/genetically engineered cells for immunotherapy

BMEMat, Volume 3, Issue 1, March 2025.
Multiple types of cells including immune cells, red blood cells, platelets, stem cells, β cells, adipocytes, and bacteria can function as cell‐derived drug carriers or genetically engineered cellular drugs according to their unique biological properties and functions for the immunotherapy of tumor, autoimmune diseases, inflammation, infectious disease,
Jingrui Shen, Yang Zhou, Lichen Yin
wiley   +1 more source

Peptides in Receptor-Mediated Radiotherapy: From Design to the Clinical Application in Cancers [PDF]

, 2013
Short peptides can show high affinity for specific receptors overexpressed on tumor cells. Some of these are already used in cancerology as diagnostic tools and others are in clinical trials for therapeutic applications. Therefore, peptides exhibit great
André Pèlegrin, Catherine Lozza, Eric Vivès, Isabelle Navarro-Teulon, Jean-Pierre Pouget   +4 more
core   +3 more sources

Hydroxylierte Aryl‐Tetrazine als bioorthogonale Scheren zur systematischen Spaltung von trans‐Cyclooctenen

Angewandte Chemie, Volume 137, Issue 5, January 27, 2025.
Hochreaktive Aryl‐Tetrazine werden häufig für schnelle bioorthogonale Ligationsreaktionen eingesetzt. Ihre Anwendung zur Click‐ausgelösten Bindungsspaltung ist aufgrund der begrenzten Spaltungseffizienz jedoch limitiert. Um dieses Problem zu lösen, wurden Hydroxyl‐Funktionalitäten eingeführt, um die Post‐Click‐Tautomerisierung zu dirigieren und zu ...
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr, Andreas Löffler, Stefan Kronister, Andres Fernandez del Castillo, Marion Goldeck, Rastislav Dzijak, Michal Rahm, Milan Vrabel, Dennis Svatunek, Jonathan C. T. Carlson, Hannes Mikula   +13 more
wiley   +1 more source

Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes

Angewandte Chemie International Edition, Volume 64, Issue 5, January 27, 2025.
Highly reactive aryl‐tetrazines are widely used for fast bioorthogonal ligation. However, their application in click‐to‐release chemistry has been impeded by significantly limited release efficiency. To address this challenge, we introduced hydroxyl functionalities to direct and accelerate post‐click tautomerization, resulting in hydroxyaryl‐tetrazines
Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr, Andreas Löffler, Stefan Kronister, Andres Fernandez del Castillo, Marion Goldeck, Rastislav Dzijak, Michal Rahm, Milan Vrabel, Dennis Svatunek, Jonathan C. T. Carlson, Hannes Mikula   +13 more
wiley   +1 more source

Produção da proteína recombinante anexina V humana em cultivos de Escherichia coli em batelada alimentada [PDF]

, 2013
Annexin V is an endogenous human protein Ca+2 dependent, with a molecular weight of 35. 8 kDa, widely distributed intracellularly, with very high concentrations in the placenta and lower concentrations in endothelial cells, kidneys, myocardium, skeletal ...
Marder, Laura Schirmbeck
core  

Predicting acquirers of US food and agribusiness firms

Agribusiness, Volume 41, Issue 1, Page 60-83, Winter 2025.
Abstract To fill an important gap in the literature on acquirer prediction, this paper investigates which factors contribute to the likelihood that a firm will choose to acquire a target company from the United States (US) food and agribusiness industry (FABI).
Ramyani Mukhopadhyay, Adesoji O. Adelaja
wiley   +1 more source

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]

, 2009
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave.
Janusz Wesolowski, Vanina Alzogaray, Jan Reyelt, Mandy Unger, Karla Juarez, Mariela Urrutia, Ana Cauerhff, Welbeck Danquah, Björn Rissiek, Felix Scheuplein, Nicole Schwarz, Sahil Adriouch, Olivier Boyer, Michel Seman, Alexei Licea, David V. Serreze, Fernando A. Goldbaum, Friedrich Haag, Friedrich Koch-Nolte, OH Brekke, C Hamers-Casterman, S Muyldermans, P Holliger, A Desmyter, E De Genst, TT Wu, MM Harmsen, A Pini, HR Hoogenboom, V Cortez-Retamozo, M Dumoulin, EK Conrath, U Rothbauer, A Olichon, K Coppieters, N Pant, D Gueorguieva, SA Jobling, B Serruys, M Feldmann, N Lonberg, A Drucker, JW Goding, M Salmi, D Corda, A Zolkiewska, F Di Virgilio, F Koch-Nolte, S Adriouch, F Koch-Nolte, F Scheuplein, S Adriouch, M Seman, V Ghetie, G Behar, AJ Groot, A Muruganandam, A Abulrob, V Cortez-Retamozo, K Omidfar, R Roovers, L Huang, BM Tijink, F Rahbarizadeh, D Ahmadvand, MA Palladino, DR Maass, W Wolfson, JJ Hulstein, D Schenk, M Dumoulin, P Lafaye, G Habicht, R Klooster, C Cohen-Saidon, C Avignolo, AJ Groot, AJ Groot, P Verheesen, D Laune, A Marquardt, DA Laplagne, LM Zarebski, DP Simmons, T Gura, K Strebhardt, K Aktories, ER Goldman, JL Liu, ER Goldman, M El Khattabi, RA Harrison, F Meddeb-Mouelhi, RA Harrison, CS Stewart, I Hmila, PJ Doyle, S Spinelli, RC Ladenson, GP Anderson, N Alvarez-Rueda, DM Goldenberg, A Forsman, L Garaicoechea, MM Harmsen, MM Harmsen, A Hultberg, HJ de Haard, AM Ledeboer, S Dekker, LJ Sherwood, MM Harmsen, A Szynol, C Krüger, KV Korotkov, AY Lam, S Spinelli, KE Conrath, B Stijlemans, TN Baral, D Saerens, L Ratier, N Deckers, E Dolk, AS Greenberg, C Vincke, X Zou, R Janssens, EG Hofman, LO Gainkam, F Rahbarizadeh, S Winichayakul, D Saerens, D Saerens, PH Chan, A Chartier, S van Koningsbruggen, JL Liu, JM van der Vaart, MM Harmsen, KA Henderson, W DeLano, RL Stanfield, AT Hadfield, BC Braden, MR Bazl, U Rothbauer   +146 more
core   +3 more sources

Phospholipid Detection From Surgical Smoke Distinguishes Basal Cell Carcinoma: A Proof‐of‐Principle Study

Dermatologic Therapy, Volume 2025, Issue 1, 2025.
Background: Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer and the most common malignancy in Caucasians. Diagnostics and treatment of BCC cause significant health‐related stress for many patients and costs for public health care systems. Differential mobility spectrometry (DMS) is a sensitive method for detection of gaseous molecules.
Anni Salminen, Patrik Sioris, Juha Jernman, Nele Veide, Anton Kontunen, Meri Mäkelä, Markus Karjalainen, Minna Kelloniemi, Niku Oksala, Antti Roine, Ioannis D. Bassukas   +10 more
wiley   +1 more source

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds [PDF]

, 2017
Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit ...
Abhishek Saxena, Donghui Wu, Hongyan Liu, Sachdev S. Sidhu   +3 more
core   +1 more source