Results 81 to 90 of about 2,392 (196)
Pretargeted delivery of PEG-coated drug carriers to breast tumors using multivalent, bispecific antibody against polyethylene glycol and HER2 [PDF]
, 2019 Pretargeting is an increasingly explored strategy to improve nanoparticle targeting, in which pretargeting molecules that bind both selected epitopes on target cells and nanocarriers are first administered, followed by the drug-loaded nanocarriers ...
Jacobs, Timothy M +6 more
core +2 more sources
The Journal of Pathology, Volume 266, Issue 4-5, Page 395-404, August 2025.Abstract In recent years, targeted therapies have become the standard of care for refractory/relapsed mantle cell lymphoma (MCL). Although the mutational profile of MCL has been extensively studied, there is a lack of understanding of resistance mechanisms and genetic factors that impact the response to novel treatments.
Tamás László +19 more
wiley +1 more source
Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors. [PDF]
, 2013 [Purpose]We aimed to develop a radiolabeled peptide probe for the imaging of hypoxia-inducible factor-1 (HIF-1)-active tumors. [Procedures]We synthesized the peptide probes that contain or lack an essential sequence of the oxygen-dependent degradation of
Kizaka-Kondoh, Shinae +5 more
core +1 more source
Bioorthogonal Click‐to‐Release of Branched Pro‐Fluorophores
Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.Alkene‐azide click‐to‐release branched prodrugs can amplify the amount of cargo activated. However, balance between the “click” and “release” steps is essential. Branched pro‐fluorophores provided the fastest‐to‐date click reaction of aryl azides and TCOs. The second branched core enabled the self‐immolation, releasing higher levels of fluorophore than
Thomasin Brind +5 more
wiley +1 more source
Click-Mediated Pretargeted Radioimmunotherapy of Colorectal Carcinoma [PDF]
Molecular Pharmaceutics, 2018 Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) represents a promising strategy for leveraging the affinity and specificity of antibodies without their pharmacokinetic drawbacks.
Rosemery Membreno +4 more
openaire +2 more sources
Frontiers in Medicine, 2015 Objectives. A phase I pretargeted radioimmunotherapy trial (EudractCT 200800603096) was designed in patients with metastatic lung cancer expressing carcinoembryonic antigen (CEA) to optimize bispecific antibody and labelled peptide doses, as well as the ...
Caroline eBodet-Milin +23 more
doaj +1 more source
Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term [PDF]
, 2015 Objective: Avidin exhibits ideal characteristics for targeted intra-cartilage drug delivery: its small size and optimal positive charge enable rapid penetration through full-thickness cartilage and electrostatic binding interactions that give long half ...
Bajpayee, Ambika Goel +3 more
core +1 more source
A Spatially Distributed Microneedle System for Bioorthogonal T Cell‐Guided Cancer Therapy
Advanced Science, Volume 12, Issue 13, April 3, 2025.A spatially distributed microneedle system (SDMNS) comprises two dissolving microneedles: DBCO‐αCD3/28@MNs, which activate T cells and label them with bioorthogonal groups in lymph nodes, and IP10‐Az@MNs, which label tumor cells and guide T cell migration.
Lanya Li +11 more
wiley +1 more source
In Vivo Radionuclide Generators for Diagnostics and Therapy [PDF]
, 2016 In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb
Edem, Patricia E. +4 more
core +3 more sources
Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology
Advanced Science, Volume 12, Issue 9, March 6, 2025.This review provides a comprehensive and timely overview of the recent advances in scaffolded bioorthogonal catalysts. It discusses the design principles, mechanisms of action, and distinct features of these novel catalysts. Besides, it also emphasizes the potential impact of these unique catalysts on advancing bioorthogonal chemistry and offers ...
Yan Zhang +8 more
wiley +1 more source