Results 61 to 70 of about 4,821,890 (183)
Cancers, 2021 Simple Summary Glioblastoma is the most common and lethal brain tumor in adults because it becomes resistant to virtually every treatment. Histone deacetylase 6 (HDAC6), which is located primarily in the cytoplasm, has a unique role in promoting the ...
P. Shi +9 more
semanticscholar +1 more source
The Roles of Primary cilia in Polycystic Kidney Disease
AIMS Molecular Science, 2013 Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders.
Sarmed H. Kathem +2 more
doaj +1 more source
Visualization of Astrocytic Primary Cilia in the Mouse Brain by Immunofluorescent Analysis Using the Cilia Marker Arl13b [PDF]
, 2014 In vertebrates, almost all somatic cells extend a single immotile cilium, referred to as a primary cilium. Increasing evidence suggests that primary cilia serve as cellular antennae in many types of tissues by sensing chemical or mechanical stimuli in ...
Asanuma, Masato +4 more
core +1 more source
Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
doaj +1 more source
The primary cilium influences interleukin-1 beta-induced NF kappa B signalling by regulating IKK activity [PDF]
, 2014 The primary cilium is an organelle acting as a master regulator of cellular signalling. We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and ...
A.K.T. Wann +68 more
core +1 more source
Primary cilia are lost in preinvasive and invasive prostate cancer. [PDF]
PLoS ONE, 2013 Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is known about the role of primary cilia in preinvasive and invasive prostate cancer.
Nadia B Hassounah +5 more
doaj +1 more source
Factors That Influence Primary Cilium Length [PDF]
, 2011 Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies.
Asanuma, Masato +3 more
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Mechanotransduction is a well-known mechanism by which cells sense their surrounding mechanical environment, convert mechanical stimuli into biochemical signals, and eventually change their morphology and functions.
Tien-Dung Do +3 more
doaj +1 more source
Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts [PDF]
, 2014 Bone turnover in vivo is regulated by mechanical forces such as shear stress originating from interstitial oscillatory fluid flow (OFF), and bone cells in vitro respond to mechanical loading.
Anuphan Sittichokechaiwut +9 more
core +1 more source
Primary cilia signaling mediates intraocular pressure sensation [PDF]
, 2014 Lowe syndrome is a rare X-linked congenital disease that presents with congenital cataracts and glaucoma, as well as renal and cerebral dysfunction. OCRL, an inositol polyphosphate 5-phosphatase, is mutated in Lowe syndrome.
Cantor, Louis B. +13 more
core +2 more sources