Results 11 to 20 of about 16,494 (203)

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine

Clinical Pharmacokinetics, 2020
Background and Objective A novel cocktail containing four substrates of key drug transporters was previously optimized to eliminate mutual drug–drug interactions between the probes digoxin (P-glycoprotein substrate), furosemide (organic anion transporter
Mitchell E Taub, Gerd Mikus, Martin F Fromm   +2 more
exaly   +2 more sources

Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Transient receptor potential vanilloid 2 is a calcium channel activated by probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that has recently been shown to induce positive lusitropic and inotropic effects in ...
Nathan Robbins, Mark Gilbert, Mohit Kumar, James W. McNamara, Patrick Daly, Sheryl E. Koch, Ginger Conway, Mohamed Effat, Jessica G. Woo, Sakthivel Sadayappan, Jack Rubinstein   +10 more
doaj   +2 more sources

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Frontiers in Physiology, 2018
Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl-/HCO3- exchanger, pendrin.
Sharon Barone, Sharon Barone, Jie Xu, Jie Xu, Kamyar Zahedi, Kamyar Zahedi, Marybeth Brooks, Manoocher Soleimani, Manoocher Soleimani, Manoocher Soleimani   +9 more
doaj   +2 more sources

TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease

Acta Pharmacologica Sinica, 2019
Parkinson’s disease (PD) is a multifactorial disorder characterized by progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies (LBs) consisting of misfolded α-synuclein protein.
Yu-He Yuan, Nai-Hong Chen
exaly   +2 more sources

Probenecid Inhibits Human Metapneumovirus (HMPV) Replication In Vitro and in BALB/c Mice

Viruses
Human metapneumovirus (HMPV) is an important cause of acute respiratory tract infection and causes significant morbidity and mortality. There is no specific antiviral drug to treat HMPV or vaccine to prevent HMPV.
Harrison C. Bergeron, Jackelyn Crabtree, Tamas Nagy, David E. Martin, Ralph A. Tripp   +4 more
doaj   +2 more sources

Evaluation of Probenecid Against Filovirus Replication in Vero E6 Cells [PDF]

Viruses
In human and non-human primates, filoviruses, e.g., Ebolaviruses, cause severe hemorrhagic fever for which there are few therapeutic options. While there are licensed vaccines and therapeutics for Ebola virus disease, there is no approved vaccine or ...
Kendra Alfson, Ricardo Carrion, Ralph A. Tripp, Chris Cirimotich, David E. Martin   +4 more
doaj   +2 more sources

Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication

Viruses, 2022
RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OATs ...
Jackelyn Murray, Harrison C. Bergeron, Les P. Jones, Zachary Beau Reener, David E. Martin, Fred D. Sancilio, Ralph A. Tripp   +6 more
doaj   +2 more sources

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +2 more sources

Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

CPT: Pharmacometrics & Systems Pharmacology, 2020
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu, Zeruesenay Desta, Brandon T. Gufford   +2 more
doaj   +2 more sources

Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin

PLoS ONE, 2011
Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of compounds, many of which are toxic and can be found in nature.
Paul A S Breslin
exaly   +2 more sources