Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
doaj +2 more sources
Probenecid Treatment Inhibits Replication of the Edmonston Measles Virus Strain in Vero Cells [PDF]
VirusesThere are no FDA-approved antiviral treatments for measles virus (MeV). Management is mainly supportive care. MeV treatments may include vitamin A, ribavirin, the MeV vaccine, or human immunoglobulin for pregnant patients exposed to MeV but lacking ...
Jackelyn Murray +2 more
doaj +2 more sources
Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis [PDF]
BMC Veterinary ResearchBackground Glaesserella parasuis elicits severe inflammatory responses and vascular damage, thus resulting in high mortality and morbidity in pigs; consequently, early diagnosis and treatment are critical to controlling economic losses. MicroRNAs (miRNAs)
Ling Guo +8 more
doaj +2 more sources
Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge [PDF]
BiomoleculesGlaesserella parasuis (G. parasuis) causes Glässer’s disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects.
Jingyang Li +13 more
doaj +2 more sources
Colon-Specific Delivery of Probenecid Enhances Therapeutic Activity of the Uricosuric Agent Against Rat Colitis [PDF]
PharmaceuticsBackground/Objectives: Probenecid (PBN) is a uricosuric agent that facilitates the excretion of uric acid and is used to treat gout. Here, a colon-targeted prodrug of PBN was designed to facilitate repositioning as a treatment for inflammatory bowel ...
Yeonhee Jeong +3 more
doaj +2 more sources
Evaluating Probenecid or Oseltamivir Inhibition of Influenza A Virus Replication Through Plaque Assay or Fluorescent Focus Assay Using Non-Structural Protein 1–H1N1 Venus Reporter Virus [PDF]
VirusesIt is essential to understand the molecular mechanisms of influenza antiviral therapeutics to evaluate their efficacy. Virus plaque assays are commonly used to assess the antiviral effects of drugs on virus replication; however, this method is labor ...
Jackelyn Murray +5 more
doaj +2 more sources
Sulopenem Etzadroxil/Probenecid. [PDF]
Hosp PharmEach month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees.
Baker DE, Levien TL.
europepmc +3 more sources
Cardiovascular Risks of Probenecid Versus Allopurinol in Older Patients With Gout
Journal of the American College of Cardiology, 2018 Tuhina Neogi, Eun Ha Kang, Rishi J Desai
exaly +2 more sources
Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats [PDF]
Frontiers in Molecular NeuroscienceQi Qi +14 more
doaj +2 more sources
InflammoPharmacology, 2023 Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis are not fully elucidated. Hence, the current study aimed to investigate the role of miRNA-373/P2X7/NLRP3/NF-κB trajectory in its ...
Rawan Mahfouz +5 more
semanticscholar +1 more source