Results 81 to 90 of about 16,494 (203)

Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice

Molecular Medicine Reports, 2016
Paeonol is a major phenolic compound of the Chinese herb, Cortex Moutan, and is known for its antioxidant, anti-inflammatory and antitumor properties. The present study was designed to investigate the therapeutic potential and underlying mechanisms of ...
Xiaojing Shi, Yu-hua Chen, Hao Liu, H. Qu   +3 more
semanticscholar   +1 more source

CMV Preventive and Treatment Studies in Children Undergoing Haematopoietic Stem Cell Transplant: A Systematic Review

Reviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Cytomegalovirus (CMV) is one of the most important infectious causes of morbidity and mortality in children undergoing haematopoietic stem cell transplant (HSCT). However, the evidence for preventing and treating CMV disease in children in this context remains limited. We sought to review the current available evidence regarding the prevention
Lara Fusani, Eleonora Fusco, Mariana Fonseca, Judith Breuer, Kanchan Rao, Luisa Galli, Alasdair Bamford, Seilesh Kadambari   +7 more
wiley   +1 more source

An Imidazo[2,1‐b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α‐Hemolysin by Blocking the Pullout of Its Stem Domain

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A high‐throughput cellular screen based on Ca2+ influx in U937 monocytic cells identified thiadiazoles as small‐molecule inhibitors of α‐hemolysin, a key virulence factor of Staphylococcus aureus. The thiadiazole 1 prevents pore formation by a dual mechanism that prevents stem loop unfolding as well as membrane attachment.
Vadim S. Korotkov, Peer Lukat, Raffaella Di Lucrezia, Aditya Shekhar, Carsten Degenhart, Randi Diestel, Ursula Bilitewski, Klaus Dinkel, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models

Frontiers in Cellular Neuroscience, 2019
Current therapies for Parkinson’s disease (PD) only offer limited symptomatic alleviation but fail to hamper the progress of the disease. Thus, it is imperative to establish new approaches aiming at protecting or reversing neurodegeneration in PD. Recent
Xuan He, Shuangshuang Yang, Rui Zhang, Lina Hou, Jianrong Xu, Yaer Hu, Rang Xu, Hao Wang, Yongfang Zhang   +8 more
doaj   +1 more source

PROBENECID AND ZIDOVUDINE METABOLISM

The Lancet, 1989
The effects of probenecid, a known inhibitor of glucuronidation, on the pharmacokinetics of zidovudine were assessed in eight subjects receiving zidovudine as treatment for human immunodeficiency virus infection. Zidovudine plasma concentrations were measured while subjects were receiving zidovudine alone, after 3 days of zidovudine plus 500 mg ...
D M, Kornhauser, B G, Petty, C W, Hendrix, A S, Woods, L J, Nerhood, J G, Bartlett, P S, Lietman   +6 more
openaire   +2 more sources

Cilastatin protects against imipenem-induced nephrotoxicity via inhibition of renal organic anion transporters (OATs)

Acta Pharmaceutica Sinica B, 2019
Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed.
Xiaokui Huo, Qiang Meng, Changyuan Wang, Yanna Zhu, Zhihao Liu, Xiaodong Ma, Xiaochi Ma, Jinyong Peng, Huijun Sun, Kexin Liu   +9 more
doaj   +1 more source

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.

Bioorganic & Medicinal Chemistry, 2015
Novel Probenecid-based amide derivatives, incorporating different natural amino acids, were synthesized and assayed to test their effect on the human carbonic anhydrase (hCA, EC 4.2.1.1) transmembrane isoforms hCA IX and XII over the ubiquitous isoforms ...
A. Mollica, Roberto Costante, A. Akdemir, S. Carradori, A. Stefanucci, G. Macedonio, M. Ceruso, C. Supuran   +7 more
semanticscholar   +1 more source

Effects of treadmill exercise on hippocampal neurogenesis in an MPTP /probenecid-induced Parkinson’s disease mouse model

Journal of Physical Therapy Science, 2015
[Purpose] This study aimed to investigate the effect of treadmill exercise on non-motor function, specifically long-term memory, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson’s disease mouse model. [Methods] A mouse model
Yun-Hee Sung
semanticscholar   +1 more source

Evaluación del ribósido de alopurinol contra la leishmaniasis cutánea ecuatoriana

Biomédica: revista del Instituto Nacional de Salud, 1995
Se realizó un estudio randomizado de 75 pacientes con leishmaniasis cutánea ecuatoriana con el fin de determinar el índice terapéutico de una nueva droga oral antileishmania, el ribósido de alopurinol más probenecid. Este agente fue evaluado comparándolo
Martha Chico, Rodrigo Armijos, Támara Mancero, Ronald H. Guderian   +3 more
doaj   +1 more source

Synthesis, Characterization, and Analysis of Probenecid and Pyridine Compound Salts

Crystals
This study aimed to address the issue of the low solubility in the model drug probenecid (PRO) and its impact on bioavailability. Two salts of probenecid (PRO), 4-aminopyridine (4AMP), and 4-dimethylaminopyridine (4DAP) were synthesized and characterized
Menglong Zhang, Xinyu Hou, Fuhai Yu, Liang Zhang, Baohong Hou, Lina Zhou, Chuang Xie, Songgu Wu, Wei Chen   +8 more
doaj   +1 more source