Results 51 to 60 of about 78,645 (243)

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Procalcitonin Level Differences in Patients with Liver Cirrhosis Without Bacterial Infection

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2017
Background: Procalcitonin level can increase in patients with liver cirrhosis without bacterial infection. The aim of this study is to identify the role of procalcitonin in patients with liver cirrhosis without bacterial infection.
Oska Mesanti, Rino Alvani Gani, Marcellus Simadibrata, Suhendro   +3 more
doaj   +1 more source

Procalcitonin to guide taking blood cultures in the intensive care unit; a cluster-randomized controlled trial [PDF]

, 2017
Objectives: We aimed to study the safety and efficacy of procalcitonin in guiding blood cultures taking in critically ill patients with suspected infection.
Duran, S., Geest, P.J. (Patrick) van der, Groeneveld, A.B.J. (Johan), Mohseni, M. (Mostafa), Nieboer, D. (Daan)   +4 more
core   +1 more source

Spherical Nucleic Acid Stabilized Cage Type Three‐Dimensional Electrochemiluminescence Probe for Sensitive and Amplification‐Free Diagnosis of Infectious Diseases

Exploration, EarlyView.
This work developed a spherical nucleic acid stabilized cage‐type 3D electrochemiluminescence reporter probe for amplification‐free and ultrasensitive detection of pathogenic. Furthermore, a hand‐held detection device was designed, and we established a straightforward workflow enabling sample to answer within 15 min.
Yu Fu, Wenlu Song, Jinyan Lin, Wei Wang, Lunjing Liu, Wenjie Wu, Huiyi Yang, Jingru Wang, Yang Yang, Bowen Shu, Yideng Jiang, Yuhui Liao   +11 more
wiley   +1 more source

Exploration of the Acceptance of the Use of Procalcitonin Point-of-Care Testing and Lung Ultrasonography by General Practitioners to Decide on Antibiotic Prescriptions for Lower Respiratory Infections: A Qualitative Study

BMJ Open, 2023
Objectives We aimed to explore the acceptance and opinions of general practitioners (GPs) on the use of procalcitonin point-of-care and lung ultrasonography for managing patients with lower respiratory tract infections in primary care.
Andreas Kronenberg, Nicolas Senn, Loïc Lhopitallier, Yolanda Mueller, Jean-Yves Meuwly, Noémie Boillat-Blanco, Daniel Geis, Nina Canova, Fabienne Fasseur   +8 more
doaj   +1 more source

The Ability of Serum Amyloid A to Discriminate Coronavirus Disease 2019 (COVID‐19) Patients Who Stay Moderately Ill Versus Patients Who Become Severely Ill

Journal of Clinical Laboratory Analysis, EarlyView.
– The aim of this study was to determine the discriminative ability of SAA, C‐reactive protein (CRP), ferritin, and procalcitonin (PCT) in patients with COVID‐19 to differentiate between those who remain moderately ill from patients who become severely ill within 7 days of hospitalization. – This study shows no differences in concentration of SAA, CRP,
Nadine M. C. Pouw, Tessa Noordermeer, Bianca Boxma‐de Klerk, Erwin Birnie, Evert‐Jan Wils, Simone Rauh, Gert‐Jan Braunstahl, Sander Mol, Ellen M. van der Zwan‐van Beek   +8 more
wiley   +1 more source

Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we investigated a rare case of γ‐heavy chain disease (γ‐HCD) through an integrated laboratory approach. Routine protein analyses (serum protein electrophoresis, immunotyping, and serum/urine immunofixation) identified an IgG monoclonal component without detectable light chains.
Eleonora Longhi, Artan Çeka, Fabiola Olivieri, Marco Moretti, Jacopo Sabbatinelli   +4 more
wiley   +1 more source

The use and misuse of procalcitonin in the management of pneumonia: a retrospective analysis at a large tertiary care center

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: Antibiotics overuse leads to bacterial resistance. The biomarker procalcitonin rises with bacterial pneumonias and remains normal in viral respiratory tract infections.
Doris C. Obimba, Aaron Shaykevich, Danielle R. Vitale, Christopher A. Rudmann, Heather Korrie, Joseph Miles, Christopher Noel, Ivayla I. Geneva   +7 more
doaj   +1 more source

Combination of Procalcitonin Value on Hospital Admission and Its Subsequent Change in Value Is Associated With the Prognosis of Sepsis

Critical Care Explorations, 2021
Objectives:. To evaluate the relationship between the procalcitonin value in blood on hospital admission and its subsequent change and prognosis among sepsis patients. Design:. A single-center, retrospective, observational study. Setting:.
Arisa Muratsu, MD, Takashi Muroya, MD, PhD, Yusuke Katayama, MD, PhD, Kentaro Shimizu, MD, PhD, Hiroshi Ogura, MD, PhD, Yasuyuki Kuwagata, MD, PhD, Takeshi Shimazu, MD, PhD   +6 more
doaj   +1 more source

Derivation and validation of the Pediatric Community‐Acquired Pneumonia Severity (PedCAPS) score: A prospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Introduction Community‐acquired pneumonia (CAP) is a frequent and costly cause of pediatric emergency department (ED) visits and hospitalizations. Previous prognostic tools for CAP are limited by small samples, single‐center or retrospective designs, lack of generalizability to ED settings, lack of biomarkers, or limited objective data.
Todd A. Florin, Ron Reeder, Lilliam Ambroggio, Richard M. Ruddy, Samir S. Shah, Allison Cator, Matthew J. Lipshaw, Geoffrey A. Capraro, Laura F. Sartori, Amy Y. Cheng, Leah Tzimenatos, Patrick S. Walsh, Claudia R. Morris, Chris A. Rees, Son H. McLaren, Tamar R. Lubell, Chari D. Larsen, Justin Moher, Eileen J. Klein, Shubhada Hooli, Nathan Kuppermann, Pediatric Emergency Care Applied Research Network (PECARN) PedCAPS Investigators   +21 more
wiley   +1 more source