Results 41 to 50 of about 69,156 (235)

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Procalcitonin in Critical Illness

Critical Care and Resuscitation, 2001
To detail the biology and diagnostic usefulness of serum procalcitonin in critical illness.A review of articles published in peer reviewed journals from 1990 to 2001 and identified through a MEDLINE search on procalcitonin.Procalcitonin (PCT) is a prohormone of calcitonin.
E, O'Connor, B, Venkatesh, J, Lipman, C, Mashongonyika, J, Hall   +4 more
openaire   +2 more sources

Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer [PDF]

, 2012
Background: Febrile neutropenia is a frequently occurring and occasionally life-threatening complication of treatment for childhood cancer. Many biomarkers have been proposed as predictors of adverse events.
Phillips Robert S, Lesley A. Stewart (7689776), Alex J. Sutton (7579679), Wade Ros, Ros Wade, Phillips, Robert S., Alex J Sutton, Lehrnbecher Thomas, Robert S Phillips, Wade, Ros, Lesley A Stewart, Lehrnbecher, Thomas, Sutton Alex J, Thomas Lehrnbecher (111156), Robert S. Phillips (320753), Stewart, Lesley A., Sutton, Alex J., Ros Wade (5740763), Thomas Lehrnbecher, Stewart Lesley A   +19 more
core   +2 more sources

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Procalcitonin in Takayasu Arteritis [PDF]

The Journal of Rheumatology, 2014
To the Editor: Procalcitonin (PCT) is an acute-phase protein, a precursor of the hormone calcitonin1. Microbial constituents and proinflammatory mediators such as tumor necrosis factor-α (TNF), interleukin 6 (IL-6), and interferon-γ induce ubiquitous PCT expression during bacterial, parasitic, or fungal infections1,2.
Tombetti E, DI Chio MC, Sartorelli S, Segalini A, Vella Y, Spalluto M, Sabbadini MG, Baldissera E, MANFREDI , ANGELO ANDREA M. A.   +8 more
openaire   +3 more sources

Relationship Between CRP, Procalcitonin, I/T Ratio and The Incidence of Sepsis in Children [PDF]

, 2023
Background: Sepsis is body immune response due to infection. Sepsis is a medical emergency condition with high-risk of mortality. WHO in 2018 stated that every year there were 2.9 million cases of death due to sepsis.
Edward Kurnia Setiawan LIMIJADI, Galuh HARDANINGSIH, Nahwa ARKHAESI, Nissa Salsabila WINARNO, MULYONO   +4 more
core   +2 more sources

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Serum procalcitonin as an early inflammatory marker in pediatric ventilator-associated pneumonia: A prospective observational study

Journal of Pediatric Critical Care, 2021
Background: Delayed diagnosis of ventilator-associated pneumonia (VAP) in pediatric patients is associated with accentuated risk of morbidities and mortality. Early diagnosis of VAP is challenging.
Devki Nandan, Manju Nimesh, Sushil Kumar, Lucky Manik, J Sudarshan, Nandini Duggal   +5 more
doaj   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source