Results 51 to 60 of about 61,936 (249)

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Canine Procalcitonin Messenger RNA Expression [PDF]

, 2008
Procalcitonin is considered an acute phase protein used as both a marker of infection and prognosis in human medicine. Canine procalcitonin has been previously sequenced; however, its use as a diagnostic or prognostic tool in dogs has never been ...
Eyal Klement, Keren Peleg, Ohad Karnieli, Itamar Aroch, Gillian Dank, Sharon Kuzi   +5 more
core   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Diagnosis by Resolution: Ultrasound Follow‐Up of Neonatal Polypoid Cystitis Mimicking Botryoid Rhabdomyosarcoma

Journal of Clinical Ultrasound, EarlyView.
In neonatal bladder masses, benign inflammatory conditions like polypoid cystitis can mimic malignancy on ultrasound. In stable neonates with evidence of infection, short‐interval ultrasound follow‐up after antibiotic therapy allows “diagnosis by resolution.” This conservative approach safely avoids unnecessary invasive procedures while maintaining ...
Davide Meneghesso, Mattia Pasquinucci, Martina Bruniera, Filippo Carletti, Alessandro Morlacco   +4 more
wiley   +1 more source

Exploration of the Acceptance of the Use of Procalcitonin Point-of-Care Testing and Lung Ultrasonography by General Practitioners to Decide on Antibiotic Prescriptions for Lower Respiratory Infections: A Qualitative Study

BMJ Open, 2023
Objectives We aimed to explore the acceptance and opinions of general practitioners (GPs) on the use of procalcitonin point-of-care and lung ultrasonography for managing patients with lower respiratory tract infections in primary care.
Andreas Kronenberg, Nicolas Senn, Loïc Lhopitallier, Yolanda Mueller, Jean-Yves Meuwly, Noémie Boillat-Blanco, Daniel Geis, Nina Canova, Fabienne Fasseur   +8 more
doaj   +1 more source

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, EarlyView.
Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial stewardship ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

Factors Associated with Post-rewarming Procalcitonin Levels in Newborns with Hypoxic Ischemic Encephalopathy [PDF]

Objective: To determine the factors associated with the procalcitonin levels in newborns with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia (TH).
Aslı Okbay Güneş, Aydın Bozkaya, Mehmet Emin Avlanmis   +2 more
core   +1 more source

Overruling of Procalcitonin-Guided Antibiotics for Lower Respiratory Tract Infections in Primary Care: Ancillary Study of a Randomized Controlled Trial [PDF]

, 2023
Background: Lower respiratory tract infections (LRTIs) in primary care are a promising target for antibiotic stewardship. A clinical trial in Switzerland showed a large decrease in antibiotic prescriptions with procalcitonin guidance (cut-off < 0.25 µg/L)
Mamin, Aline, Onya Opota, Aline Mamin, Page, Marie-Anne, Boillat-Blanco, Noémie, Isabella Locatelli, Perrenoud, M.A., Perrenoud, Marc-Antoine, Lhopitallier, L., José Knüsli, Opota, Onya, Senn, Nicolas, Valérie D’Acremont, Nicolas Senn, Kronenberg, A., Locatelli, Isabella, Mueller, Y., Meuwly, Jean-Yves, Kain, Kevin C, Meuwly, J.Y., Mamin, A., Locatelli, I., Marc-Antoine Perrenoud, Knüsli, José, Kevin C. Kain, Knüsli, J., Senn, N., Marie-Anne Page, Boillat-Blanco, N., Kain, K.C., D'Acremont, Valérie, Mueller, Yolanda, Andreas Kronenberg, Yolanda Mueller, D'Acremont, V., Loïc Lhopitallier, Jean-Yves Meuwly, Page, M.A., Noémie Boillat-Blanco, Opota, O., Kronenberg, Andreas, Lhopitallier, Loïc   +41 more
core   +1 more source

The use and misuse of procalcitonin in the management of pneumonia: a retrospective analysis at a large tertiary care center

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: Antibiotics overuse leads to bacterial resistance. The biomarker procalcitonin rises with bacterial pneumonias and remains normal in viral respiratory tract infections.
Doris C. Obimba, Aaron Shaykevich, Danielle R. Vitale, Christopher A. Rudmann, Heather Korrie, Joseph Miles, Christopher Noel, Ivayla I. Geneva   +7 more
doaj   +1 more source

Combination of Procalcitonin Value on Hospital Admission and Its Subsequent Change in Value Is Associated With the Prognosis of Sepsis

Critical Care Explorations, 2021
Objectives:. To evaluate the relationship between the procalcitonin value in blood on hospital admission and its subsequent change and prognosis among sepsis patients. Design:. A single-center, retrospective, observational study. Setting:.
Arisa Muratsu, MD, Takashi Muroya, MD, PhD, Yusuke Katayama, MD, PhD, Kentaro Shimizu, MD, PhD, Hiroshi Ogura, MD, PhD, Yasuyuki Kuwagata, MD, PhD, Takeshi Shimazu, MD, PhD   +6 more
doaj   +1 more source