Results 161 to 170 of about 2,732 (185)

Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson-Gilford Progeria Syndrome. [PDF]

Diseases
Lederer EM, Fenzl FQ, Krüger P, Schroll M, Hartinger R, Djabali K.   +5 more
europepmc   +1 more source

The anti-senescence effect of D-β-hydroxybutyrate in Hutchinson-Gilford progeria syndrome involves progerin clearance by the activation of the AMPK-mTOR-autophagy pathway. [PDF]

Geroscience
Monterrubio-Ledezma F, Salcido-Gómez A, Zavaleta-Vásquez T, Navarro-García F, Cisneros B, Massieu L.   +5 more
europepmc   +1 more source

Analysis of Beta-Dystroglycan in Different Cell Models of Senescence. [PDF]

Int J Mol Sci
Jimenez-Gutierrez GE, Zavaleta-Vásquez TI, Lizcano-Meneses JA, Garcia-Aguirre IA, Laredo-Cisneros MS, Magaña JJ, Winder SJ, Cordero-Martínez J, Cisneros B.   +8 more
europepmc   +1 more source

Disease pathogenicity in Hutchinson-Gilford progeria syndrome mice: insights from lung-associated alterations. [PDF]

Mol Med
Wang J, Guan Y, Wang Y, Tan J, Cao Z, Ding Y, Gao L, Fu H, Chen X, Lin J, Shen N, Fu X, Wang F, Mao J, Hu L.   +14 more
europepmc   +1 more source

Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders. [PDF]

Neurosci Appl
He B, Smedler E.
europepmc   +1 more source

Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice. [PDF]

Front Immunol
Sun Q, Yang L, Zhou Z, Wu N, Li C, Hu Q, Cong X.   +6 more
europepmc   +1 more source

High Body Mass Index is Associated with Elevated Blood Levels of Progerin mRNA [PDF]

International Journal of Molecular Sciences, 2019
Obesity is a well-described risk factor resulting in premature aging of the cardiovascular system ultimately limiting longevity. Premature cardiac death and aging is the hallmark of Hutchinson–Gilford syndrome (HGPS), a disease caused by defined ...
Marc-Michael Zaruba
exaly   +2 more sources

Antisense-Based Progerin Downregulation in HGPS-Like Patients’ Cells [PDF]

Cells, 2016
Progeroid laminopathies, including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging diseases caused by defects in nuclear A-type Lamins. Most HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type Lamins.
Nicolas Levy, Claire Navarro
exaly   +4 more sources

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Progerin and Its Role in Accelerated and Natural Aging

Molecular Biology, 2022
Well-known theories of aging suggest that a certain metabolic defect negatively affects vital activity of the cell, be it oxidative stress, the accumulation of lesions in DNA, the exhaustion of telomeres, or distorted epigenetic processes. The theory of aging considered in the review postulates that an accumulation of progerin on the inner side of the ...
openaire   +2 more sources

Corruption of DNA end-joining in mammalian chromosomes by progerin expression

DNA Repair, 2023
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging and a life expectancy of about 14 years. HGPS is commonly caused by a point mutation in the LMNA gene which codes for lamin A, an essential component of the nuclear lamina.
Liza A, Joudeh, Alannah J, DiCintio, Madeline R, Ries, Andrew S, Gasperson, Kennedy E, Griffin, Victoria P, Robbins, Makenzie, Bonner, Sarah, Nolan, Emma, Black, Alan S, Waldman   +9 more
openaire   +2 more sources