Results 151 to 160 of about 2,950 (183)

Therapeutic RNA cleavage with RfxCas13d in Hutchinson-Gilford progeria syndrome. [PDF]

Mol Ther
Zheng C.
europepmc   +1 more source

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells. [PDF]

Aging Pathobiol Ther
Joruiz SM, Lissa D, Von Muhlinen N, Dranchak PK, Inglese J, Horikawa I, Harris CC.   +6 more
europepmc   +1 more source

Deep Profiling of the Aging Proteome Depicts Neuroinflammation, Synaptic Function, and Phosphorylation in an Accelerated Alzheimer's Disease Cell Model. [PDF]

Mol Cell Proteomics
Gentry E, Islam MT, Xue H, Cao K, Nemes P.   +4 more
europepmc   +1 more source

A longevity-associated variant of the human BPIFB4 gene prevents diastolic dysfunction in progeria mice. [PDF]

Signal Transduct Target Ther
Qiu Y, Cattaneo M, Maciag A, Puca AA, Madeddu P.   +4 more
europepmc   +1 more source

Expression of progerin enhances disease-related endpoints in a tau seeding reporter cell system. [PDF]

Geroscience
Han ZZ, Kang SG, Gomez-Cardona E, Wohlgemuth S, Shmeit K, Arce L, Safar JG, Julien O, Westaway D.   +8 more
europepmc   +1 more source

Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease. [PDF]

Nat Aging
Revêchon G, Witasp A, Viceconte N, Helgadottir HT, Machtel P, Stefani F, Whisenant D, Sola-Carvajal A, McGuinness D, Abutaleb NO, Artiach G, Arzt EW, Soveri I, Babler A, Ziegler S, Kramann R, Bäck M, Thorell A, Truskey GA, Wennberg L, Shiels PG, Wernerson A, Stenvinkel P, Eriksson M.   +23 more
europepmc   +1 more source

Precise progerin targeting using RfxCas13d: A therapeutic avenue for Hutchinson-Gilford progeria syndrome. [PDF]

Mol Ther
Chae U, Yang HJ, Kim H, Lee SH, Lee DG, Koo JY, Ha SM, Bak SJ, Joo M, Nam HH, Lim KS, Kang P, Son HC, An YJ, Kim YH, Song IS, Lee SH, Kim HR, Cho SM, Kim EK, Nam KH, Chung KS, Kim JY, Kim SY, Kim SK, Kim SY, Lee DS, Kim JM, Park YH, Kim SU.   +29 more
europepmc   +1 more source

White adipose atrophy exacerbates cold stress and accelerates aging in male mice. [PDF]

Nat Commun
Liu Z, Hu W, Tan X, Sun S, Huang X, Meng Y, Zhao N, Wang M, Wu W, Qian M, Tang X, Pang Q, Wang Z, Su W, Liu B.   +14 more
europepmc   +1 more source

A noncanonical cGAS-STING pathway drives cellular and organismal aging. [PDF]

Proc Natl Acad Sci U S A
Cancado de Faria R, Silva LND, Teodoro-Castro B, McCommis KS, Shashkova EV, Gonzalo S.   +5 more
europepmc   +1 more source

The dual guardians of cellular stability: exploring nesprin and lamin in senescence. [PDF]

Cell Death Dis
Zhou ZY, Qin Q, Dong C, Liu Y, Cao C, Teng L.   +5 more
europepmc   +1 more source