Results 151 to 160 of about 3,871 (195)

Involvement of NRF2 and AMPK signaling in aging and progeria: a digest. [PDF]

Redox Biol
Petsouki E, Gerakopoulos V, Gianniou DD, Heiss EH, Trougakos IP.   +4 more
europepmc   +1 more source

Current potential health benefits of sulforaphane [PDF]

Kim, Jae Kwang, Park, Sang Un
core   +1 more source

Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope. [PDF]

Curr Issues Mol Biol
Kamikawa Y, Wu Z, Fujise K, Imaizumi K, Saito A.   +4 more
europepmc   +1 more source

Experimental Confirmation of Progerin–Small Peptide Interaction Using NanoLuc Binary Technology Assay in Human Cell Lines to Validate in Silico–Designed Progerin Interactors

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder characterized by accelerated aging, primarily caused by the accumulation of a mutant form of lamin A known as progerin. One of the hallmarks of HGPS is increased oxidative stress, often associated with elevated levels of reactive oxygen species (ROS). In this study, we employed flow
openaire   +1 more source

Progerin mRNA Is Associated with Smoking and Signs of Increased Microvascular Damage in Patients with Diabetic Macular Edema. [PDF]

Int J Mol Sci
Zaruba MM, Angermann R, Staggl S, Jeyakumar V, Mair S, Stöckl V, Neyer J, Maurer T, Ungericht M, Gavranovic-Novakovic J, Bauer A, Zehetner C, Messner M.   +12 more
europepmc   +1 more source

National survey of Hutchinson-Gilford progeria syndrome and progeroid laminopathy in Japan. [PDF]

Aging (Albany NY)
Okawa Y, Matsuo M, Kosaki R, Tonoki H, Fujimoto M, Ozono K, Saitou H, Kubota T, Ohata Y, Namba N, Akaboshi S, Komaki H, Inagaki N, Kato E, Maruo Y, Yonekawa T, Nakamura T, Hayashi K, Miwa S, Magota M, Ihara K.   +20 more
europepmc   +1 more source

Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation. [PDF]

Commun Biol
Picotto J, Bertrand P, Pennarun G.
europepmc   +1 more source

Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice. [PDF]

Int J Mol Sci
Krüger P, Schroll M, Fenzl FQ, Hartinger R, Lederer EM, Görlach A, Gordon LB, Cavalcante P, Iacomino N, Rathkolb B, Pimentel JAA, Östereicher M, Spielmann N, Wolf CM, de Angelis MH, Djabali K.   +15 more
europepmc   +1 more source

Lonafarnib Clinical Trials Demonstrate Uncoupling of the Muscle-Bone Unit in Hutchinson-Gilford Progeria Syndrome. [PDF]

J Bone Miner Res
Kreienkamp RJ, Gordon LB, Ehrbar R, Pendleton A, Schiferl DJ, Lyass A, Kleinman ME, Snyder BD, Gordon CM.   +8 more
europepmc   +1 more source

Old enough to be a model? On the role of maturity in stem cell-based models for neuropsychiatric disorders. [PDF]

Neurosci Appl
He B, Smedler E.
europepmc   +1 more source