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Nucleocytoplasmic transport in cells with progerin-induced defective nuclear lamina
Biophysical Chemistry, 2017Recent data indicate that nuclear lamina (NL) plays a relevant role in many fundamental cellular functions. The peculiar role of NL in cells is dramatically demonstrated by the Hutchinson-Gilford progeria syndrome (HGPS), an inherited laminopathy that causes premature, rapid aging shortly after birth.
Ferri G, Storti B, Bizzarri R
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Abstract 12533: Progerin Causes a Disproportionate Senescence in Endothelial Cells
Circulation, 2021Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by the mutation of LMNA gene leading to irreversibly farnesylated lamin A protein, i.e. progerin. The major causes of death in HGPS are coronary and arterial occlusive disease.
Qiu Xu +5 more
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Progerin - novi uzrok starenja stanica
2011Prema današnjim spoznajama fiziološko se starenje stanice objašnjava progresivnim skraćivanjem telomernih dijelova DNA. U normalnim somatskim stanicama ovog enzima ima u minimalnim količinama pa su postupni gubitak telomera i posljedično starenje neizbježni. Nefiziološko starenje stanice mogu pokrenuti razni vanstanični ali i stanični poticaji, kao što
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Nuclear membrane deformation via progerin clustering
Biophysical Journal, 2023openaire +1 more source
The Role of Progerin in Artificially Ageing Stem Cells
Stem Cell Reviews and ReportsRachel Brown, Mubeen Goolam
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Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria
Aging Cell, 2020David Liebl +2 more
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