Results 181 to 187 of about 3,816 (187)

Corruption of DNA end-joining in mammalian chromosomes by progerin expression

DNA Repair, 2023
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging and a life expectancy of about 14 years. HGPS is commonly caused by a point mutation in the LMNA gene which codes for lamin A, an essential component of the nuclear lamina.
Liza A, Joudeh, Alannah J, DiCintio, Madeline R, Ries, Andrew S, Gasperson, Kennedy E, Griffin, Victoria P, Robbins, Makenzie, Bonner, Sarah, Nolan, Emma, Black, Alan S, Waldman   +9 more
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Nucleocytoplasmic transport in cells with progerin-induced defective nuclear lamina

Biophysical Chemistry, 2017
Recent data indicate that nuclear lamina (NL) plays a relevant role in many fundamental cellular functions. The peculiar role of NL in cells is dramatically demonstrated by the Hutchinson-Gilford progeria syndrome (HGPS), an inherited laminopathy that causes premature, rapid aging shortly after birth.
Ferri G, Storti B, Bizzarri R
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Increased progerin expression associated with unusualLMNAmutations causes severe progeroid syndromes

Human Mutation, 2007
Hutchinson-Gilford progeria syndrome (HGPS) is a rare precocious aging syndrome caused by mutations in LMNA that lead to synthesis of a mutant form of prelamin A, generally called progerin, that cannot be processed to mature lamin A. Most HGPS patients have a recurrent heterozygous de novo mutation in exon 11 of LMNA, c.1824C>T/p.G608G; this synonymous
Moulson, Casey L., Fong, Loren G., Gardner, Jennifer M., Farber, Emily A., Go, Gloriosa, Passariello, Annalisa, Grange, Dorothy K., Young, Stephen G., Miner, Jeffrey H.   +8 more
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Progerin - novi uzrok starenja stanica

2011
Prema današnjim spoznajama fiziološko se starenje stanice objašnjava progresivnim skraćivanjem telomernih dijelova DNA. U normalnim somatskim stanicama ovog enzima ima u minimalnim količinama pa su postupni gubitak telomera i posljedično starenje neizbježni. Nefiziološko starenje stanice mogu pokrenuti razni vanstanični ali i stanični poticaji, kao što
openaire   +1 more source

Nuclear membrane deformation via progerin clustering

Biophysical Journal, 2023
openaire   +1 more source

The Role of Progerin in Artificially Ageing Stem Cells

Stem Cell Reviews and Reports
Rachel Brown, Mubeen Goolam
openaire   +1 more source

Dissecting early neuronal ageing features in Progerin-overexpressing organoids

openaire   +1 more source