Promotion of tumor development in prostate cancer by progerin [PDF]
Cancer Cell International, 2010 Progerin is a truncated form of lamin A. It is identified in patients with Hutchinson-Gilford progeria syndrome (HGPS), a disease characterized by accelerated aging.
Nie Daotai +3 more
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Antisense oligonucleotide induction of progerin in human myogenic cells. [PDF]
PLoS ONE, 2014 We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene (LMNA) transcript in human myogenic cells. The progerin transcript (LMNA
Yue-Bei Luo +6 more
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Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. [PDF]
PLoS ONE, 2018 Mutations in the LMNA gene are a common cause (6-8%) of dilated cardiomyopathy (DCM) leading to heart failure, a growing health care problem worldwide. The premature aging disease Hutchinson-Gilford syndrome (HGPS) is also caused by defined mutations in ...
Moritz Messner +6 more
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New look at the role of progerin in skin aging [PDF]
Menopause Review, 2015 Current literature data indicate that progerin, which is a mutant of lamin A, may be one of several previously known physiological biomarkers of the aging process which begins at the age of 30. Lamins belong to the family of intermediate filaments type V
Anna Skoczyńska +3 more
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Progerin-Induced Impairment in Wound Healing and Proliferation in Vascular Endothelial Cells
Frontiers in Aging, 2022 Progerin as a mutated isoform of lamin A protein was first known to induce premature atherosclerosis progression in patients with Hutchinson-Gilford progeria syndrome (HGPS), and its role in provoking an inflammatory response in vascular cells and ...
Yizhi Jiang, Julie Y. Ji
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A new fluorescent probe for the visualization of progerin
Bioorganic Chemistry, 2023 Hutchinson-Gilford progeria syndrome (HGPS) or progeria is a rare genetic disease that causes premature aging, leading to a drastic reduction in the life expectancy of patients. Progeria is mainly caused by the intracellular accumulation of a defective protein called progerin, generated from a mutation in the LMNA gene.
Macicior Michelena, Jon +2 more
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Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling [PDF]
Advanced ScienceHutchinson–Gilford progeria syndrome, caused by a mutation in the LMNA gene, leads to increased levels of truncated prelamin A, progerin, in the nuclear membrane. The accumulation of progerin results in defective nuclear morphology and is associated with
Ji‐Eun Park +9 more
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Longwave UV Light Induces the Aging-Associated Progerin [PDF]
Journal of Investigative Dermatology, 2013 Premature aging in Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation of the LMNA gene that activates a cryptic splice site. This results in expression of a truncated form of Lamin A, called progerin. Accumulation of progerin in the nuclei of HGPS cells impairs nuclear functions and causes abnormal nuclear morphology.
Takeuchi, Hirotaka, Rünger, Thomas M.
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Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates. [PDF]
PLoS ONE, 2011 Closure of the ductus arteriosus (DA) at birth is essential for the transition from fetal to postnatal life. Before birth the DA bypasses the uninflated lungs by shunting blood from the pulmonary trunk into the systemic circulation.
Regina Bökenkamp +7 more
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Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells [PDF]
Nucleus, 2020 The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome.
Brooke E. Danielsson +7 more
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