Promotion of tumor development in prostate cancer by progerin [PDF]
Cancer Cell International, 2010 Progerin is a truncated form of lamin A. It is identified in patients with Hutchinson-Gilford progeria syndrome (HGPS), a disease characterized by accelerated aging.
Nie Daotai +3 more
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Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. [PDF]
PLoS ONE, 2018 Mutations in the LMNA gene are a common cause (6-8%) of dilated cardiomyopathy (DCM) leading to heart failure, a growing health care problem worldwide. The premature aging disease Hutchinson-Gilford syndrome (HGPS) is also caused by defined mutations in ...
Moritz Messner +6 more
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Antisense oligonucleotide induction of progerin in human myogenic cells. [PDF]
PLoS ONE, 2014 We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene (LMNA) transcript in human myogenic cells. The progerin transcript (LMNA
Yue-Bei Luo +6 more
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New look at the role of progerin in skin aging [PDF]
Menopause Review, 2015 Current literature data indicate that progerin, which is a mutant of lamin A, may be one of several previously known physiological biomarkers of the aging process which begins at the age of 30. Lamins belong to the family of intermediate filaments type V
Anna Skoczyńska +3 more
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Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson-Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation. [PDF]
Aging CellWe demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
García-Aguirre I +18 more
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A new fluorescent probe for the visualization of progerin
Bioorganic Chemistry, 2023 Hutchinson-Gilford progeria syndrome (HGPS) or progeria is a rare genetic disease that causes premature aging, leading to a drastic reduction in the life expectancy of patients.
Macicior Michelena, Jon +2 more
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Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates. [PDF]
PLoS ONE, 2011 Closure of the ductus arteriosus (DA) at birth is essential for the transition from fetal to postnatal life. Before birth the DA bypasses the uninflated lungs by shunting blood from the pulmonary trunk into the systemic circulation.
Regina Bökenkamp +7 more
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Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells [PDF]
Nucleus, 2020 The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome.
Brooke E. Danielsson +7 more
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Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
eLife, 2015 Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin.
Alexandre Chojnowski +15 more
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Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A [PDF]
Scientific Reports, 2021 Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late 50 s ...
So-mi Kang +11 more
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