Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
eLife, 2015 Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin.
Alexandre Chojnowski +15 more
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Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A [PDF]
Scientific Reports, 2021 Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process is initiated at puberty and the expected life span is approximately the late 50 s ...
So-mi Kang +11 more
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Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence [PDF]
Journal of Cell Science, 2010 Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a dominant mutation in the gene encoding lamin A, which leads to an aberrantly spliced and processed protein termed progerin. Previous studies have shown that progerin induces early senescence associated with increased DNA-damage signaling and that telomerase extends ...
Erica K, Benson +2 more
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New insights in Progerin-induced modifications of chromatin landscapes [PDF]
Biophysical Journal, 2023 Genome structure, expression, and regulation are crucial in maintaining the physiological state of any cell. However, even a single variation in one of these processes can induce genomic instability, leading to different pathologies, including aging and cancer.
Cainero, I +5 more
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Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy [PDF]
Molecular Therapy: Nucleic AcidsHutchinson-Gilford progeria syndrome is a fatal genetic disorder caused by a point mutation in the gene encoding the nuclear envelope protein lamin A/C.
Volha Dzianisava +3 more
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Transcriptional profiling of Hutchinson-Gilford progeria patients identifies primary target pathways of progerin [PDF]
NucleusHutchinson Gilford Progeria Syndrome (HGPS) is an ultra-rare pediatric premature aging disorder. It is caused by a point mutation in the LMNA gene leading to the production of the dominant-negative progerin isoform of the nuclear envelope protein lamin A.
Sandra Vidak, Sohyoung Kim, Tom Misteli
doaj +2 more sources
Progerin mRNA Is Associated with Smoking and Signs of Increased Microvascular Damage in Patients with Diabetic Macular Edema [PDF]
International Journal of Molecular SciencesThe premature aging disease Hutchinson–Gilford Syndrome (HGPS) is caused by defined mutations in the LMNA gene, resulting in the activation of a cryptic splice donor site, which leads to a defective truncated prelamin A protein called progerin ...
Vivek Jeyakumar +2 more
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Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time [PDF]
Scientific Reports, 2017 Accumulation of progerin is believed to underlie the pathophysiology of Hutchinson-Gilford progeria syndrome, a disease characterized by clinical features suggestive of premature aging, including loss of subcutaneous white adipose tissue (sWAT). Although
Gwladys Revêchon +9 more
doaj +2 more sources
Correction to "The Activation of cGAS-STING Pathway Causes Abnormal Uterine Receptivity in Aged Mice". [PDF]
Aging CellAging Cell, Volume 25, Issue 5, May 2026.
europepmc +2 more sources
Cardiomyocyte-Restricted Expression of Progerin Confers Cardiac Hypertrophy. [PDF]
Circ ResSubati T +5 more
europepmc +4 more sources