Results 21 to 30 of about 3,871 (195)

New look at the role of progerin in skin aging [PDF]

Menopause Review, 2015
Current literature data indicate that progerin, which is a mutant of lamin A, may be one of several previously known physiological biomarkers of the aging process which begins at the age of 30. Lamins belong to the family of intermediate filaments type V
Anna Skoczyńska, Elżbieta Budzisz, Agnieszka Dana, Helena Rotsztejn   +3 more
doaj   +3 more sources

Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time [PDF]

Scientific Reports, 2017
Accumulation of progerin is believed to underlie the pathophysiology of Hutchinson-Gilford progeria syndrome, a disease characterized by clinical features suggestive of premature aging, including loss of subcutaneous white adipose tissue (sWAT). Although
Gwladys Revêchon, Nikenza Viceconte, Tomás McKenna, Agustín Sola Carvajal, Peter Vrtačnik, Peter Stenvinkel, Torbjörn Lundgren, Kjell Hultenby, Irene Franco, Maria Eriksson   +9 more
doaj   +3 more sources

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS. [PDF]

Aging Cell
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Hartmann C, Haß C, Knobloch M, Barrantes I, Fumagalli L, Premereur J, Markert F, Peters M, Koromila G, Hartmann A, Jäger K, Abel J, Mancuso R, Storch A, Walter M, Fuellen G, Hermann A.   +16 more
europepmc   +2 more sources

miR-140-5p Overexpression Contributes to Oxidative Stress and Mitochondrial Dysfunction in Hutchinson-Gilford Progeria Syndrome Fibroblasts Through NRF2 Pathway. [PDF]

Aging Cell
This study identifies a novel molecular mechanism involving miR‐140‐5p that contributes to the pathogenesis of HGPS. By decreasing NRF2 expression, miR‐140‐5p overexpression results in downregulation of the NRF2/KEAP1/HO‐1 antioxidant pathway in HGPS fibroblasts, leading to increased oxidative stress and mitochondrial dysfunction, two hallmarks of ...
Toury L, Frankel D, Nael S, Abaji M, Le Goff L, Basset M, Airault C, Vernay B, Novoa-Del-Toro EM, Bartoli C, Baudot A, Magdinier F, Kaspi E, Roll P.   +13 more
europepmc   +2 more sources

ESCRT-III controls nuclear envelope deformation induced by progerin [PDF]

Scientific Reports, 2020
AbstractHutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by mutation in the gene encoding lamin A/C, which produces a truncated protein called progerin. In cells from HGPS patients, progerin accumulates at the nuclear membrane (NM), where it causes NM deformations. In this study, we investigated whether progerin-induced
Arii, Jun, Maeda, Fumio, Maruzuru, Yuhei, Koyanagi, Naoto, Kato, Akihisa, Mori, Yasuko, Kawaguchi, Yasushi   +6 more
openaire   +2 more sources

Cardiomyocyte-Restricted Expression of Progerin Confers Cardiac Hypertrophy. [PDF]

Circ Res
Subati T, Buehler DP, Zhong L, Miller FJ, Agrawal V, Brown JD.   +5 more
europepmc   +2 more sources

Baricitinib Augments Lonafarnib Therapy to Preserve Colonic Homeostasis and Microbial Balance in a Mouse Model of Progeria. [PDF]

Aging Cell
Combined baricitinib and lonafarnib treatment improved colonic pathology in LmnaG609G/G609G progeria mice by reducing progerin, maintaining epithelial regeneration, mitigating inflammation and senescence, and preserving microbiome composition. ABSTRACT Hutchinson‐Gilford Progeria Syndrome (HGPS) is a fatal genetic disorder caused by progerin, a mutant ...
Schroll M, Amar Y, Krüger P, Neuhaus K, Djabali K.   +4 more
europepmc   +2 more sources

A new fluorescent probe for the visualization of progerin

Bioorganic Chemistry, 2023
Hutchinson-Gilford progeria syndrome (HGPS) or progeria is a rare genetic disease that causes premature aging, leading to a drastic reduction in the life expectancy of patients. Progeria is mainly caused by the intracellular accumulation of a defective protein called progerin, generated from a mutation in the LMNA gene.
Macicior Michelena, Jon, Fernández, Daniel, Ortega Gutiérrez, Silvia   +2 more
openaire   +4 more sources

Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction

Skeletal Muscle, 2022
Background Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of the skeletal muscles.
Yaoxian Xiang, Zongqi You, Xinying Huang, Junxi Dai, Junpeng Zhang, Shuqi Nie, Lei Xu, Junjian Jiang, Jianguang Xu   +8 more
doaj   +1 more source

Systemic Problems: A perspective on stem cell aging and rejuvenation. [PDF]

, 2015
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies.
CONBOY, Irina M, Conboy, Michael, Rebo, Justin   +2 more
core   +10 more sources