Results 31 to 40 of about 3,005 (182)
Skeletal Muscle, 2022 Background Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of the skeletal muscles.
Yaoxian Xiang +8 more
doaj +1 more source
The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis. [PDF]
Biol CellWe highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Fraboulet S, Aldarawish O, Dolega ME.
europepmc +2 more sources
Modeling premature aging in yeast via the expression of Progerin. [PDF]
Aging (Albany NY)Belak ZR +5 more
europepmc +2 more sources
Expression of progerin does not result in an increased mutation rate [PDF]
Chromosome Research, 2017 In the premature ageing disease Hutchinson-Gilford progeria syndrome (HGPS), the underlying genetic defect in the lamin A gene leads to accumulation at the nuclear lamina of progerin-a mutant form of lamin A that cannot be correctly processed. This has been reported to result in defects in the DNA damage response and in DNA repair, leading to the ...
Deniaud, Emmanuelle +3 more
openaire +3 more sources
ESCRT-III controls nuclear envelope deformation induced by progerin [PDF]
Scientific Reports, 2020 AbstractHutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by mutation in the gene encoding lamin A/C, which produces a truncated protein called progerin. In cells from HGPS patients, progerin accumulates at the nuclear membrane (NM), where it causes NM deformations. In this study, we investigated whether progerin-induced
Arii, Jun +6 more
openaire +2 more sources
Correction to "The Activation of cGAS-STING Pathway Causes Abnormal Uterine Receptivity in Aged Mice". [PDF]
Aging CellAging Cell, Volume 25, Issue 5, May 2026.
europepmc +2 more sources
Progerin guilty of size discrimination [PDF]
Journal of Cell Biology, 2013 ![Figure][1] Tpr (red) accumulates in the nuclei of cells from a healthy person (left), but it remains in the cytoplasm of cells from an HGPS patient (right). A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus ...
openaire +1 more source
Longwave UV Light Induces the Aging-Associated Progerin [PDF]
Journal of Investigative Dermatology, 2013 Premature aging in Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation of the LMNA gene that activates a cryptic splice site. This results in expression of a truncated form of Lamin A, called progerin. Accumulation of progerin in the nuclei of HGPS cells impairs nuclear functions and causes abnormal nuclear morphology.
Takeuchi, Hirotaka, Rünger, Thomas M.
openaire +2 more sources
Cardiomyocyte-Restricted Expression of Progerin Confers Cardiac Hypertrophy. [PDF]
Circ ResSubati T +5 more
europepmc +4 more sources
progerin overexpression in C3h10 cells RNAseq.xls
, 2023 we overexpressed progerin in the C3H10 cell line and performed RNA sequencing analysis. 106 genes were down-regulated and 254 genes were up-regulated in progerin expressed cells with fold change greater than 1.5 and P-value less than 0.05, compared with ...
jinlong suo (15151015)
core +1 more source