A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon [PDF]
, 2012 Purpose: IFNa was the first cytokine to demonstrate anti-tumor activity in advanced melanoma. Despite the ability of high-dose IFNa reducing relapse and mortality by up to 33%, large majority of patients experience side effects and toxicity which ...
Alessandro Monaco +9 more
core +4 more sources
Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]
, 2019 BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H. +17 more
core +2 more sources
Development and internal validation of a nine-lncRNA prognostic signature for prediction of overall survival in colorectal cancer patients [PDF]
PeerJ, 2018 Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients ...
Zhiqiao Zhang +7 more
doaj +2 more sources
EBioMedicine, 2018 Background: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.
Lingjian Yang +27 more
doaj +1 more source
MRNA expression profiles of colorectal liver metastases as a novel biomarker for early recurrence after partial hepatectomy [PDF]
, 2016 Background: Identification of specific risk groups for recurrence after surgery for isolated colorectal liver metastases (CRLM) remains challenging due to the heterogeneity of the disease.
Ayez, N. (Ninos) +8 more
core +3 more sources
Prognostic and Predictive Value of an Immunoscore Signature in Glioblastoma Multiform [PDF]
Frontiers in Genetics, 2020 Although increasing evidence shows that immune infiltration plays an essential role in glioblastoma (GBM), current prognostic indicators do not accurately represent the risk of immune cells infiltration in patients. It is therefore critical to identify new prognostic markers for GBM.
Lun Gao +8 more
openaire +4 more sources
Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. [PDF]
, 2014 Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a ...
Bi, Yingtao +5 more
core +1 more source
Identification of a 9‐gene prognostic signature for breast cancer [PDF]
Cancer Medicine, 2020 AbstractBreast cancer (BRCA) is the most common cancer among women and is the second leading cause of cancer death in women. In this study, we developed a 9‐gene prognostic signature to predict the prognosis of patients with BRCA. GSE20685, GSE42568, GSE20711, and GSE88770 were used as training sets.
Zelin Tian +5 more
openaire +4 more sources
Population Ecology, EarlyView.We investigate the seasonal dynamics of two freshwater snails, Biomphalaria straminea and Melanoides tuberculata, in artificial reservoirs of the Brazilian semiarid region. Despite regulated hydrology, B. straminea exhibited strong seasonal fluctuations associated with dry periods, while M. tuberculata maintained stable populations throughout the year,
Lucas Henrique Sousa da Silva +6 more
wiley +1 more source
A Robust Gene Expression Prognostic Signature for Overall Survival in High-Grade Serous Ovarian Cancer. [PDF]
, 2019 The objective of this research was to develop a robust gene expression-based prognostic signature and scoring system for predicting overall survival (OS) of patients with high-grade serous ovarian cancer (HGSOC).
Hang, Bo +8 more
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