Results 91 to 100 of about 267,372 (195)

Computational insights on the hydride and proton transfer mechanisms of L-proline dehydrogenase. [PDF]

PLoS One, 2023
Yildiz I.
europepmc   +1 more source

Cenozoic Tectonics Ignite Mitochondrial Codon Innovations Propelling Canid Body Size Evolution and Transcontinental Radiations

Integrative Zoology, EarlyView.
We decode mitochondrial genomes across all extant canids, revealing lineage‐specific codon optimization driven by altitude, predation, and body size. A tripartite framework integrates geological events, metabolic constraints, and adaptive radiation to explain carnivore evolution.
Xiaoyang Wu, Xibao Wang, Yongquan Shang, Yao Chen, Haotian Cai, Tian Xia, Qinguo Wei, Weilai Sha, Honghai Zhang   +8 more
wiley   +1 more source

Proline dehydrogenase regulates redox state and respiratory metabolism in Trypanosoma cruzi.

, 2013
Over the past three decades, L-proline has become recognized as an important metabolite for trypanosomatids. It is involved in a number of key processes, including energy metabolism, resistance to oxidative and nutritional stress and osmoregulation.
Zimbres, Flávia Menezes, Elias, Maria Carolina, Maria Carolina Elias, Mantilla, Brian Suárez, Melo, Patrícia Diogo de, Vieira, Lisvane Paes, Kowaltowski, Alicia Juliana, Tahara, Erich Birelli, Silber, Ariel Mariano, Ariel Mariano Silber, Patrícia Diogo de Melo, Elisabeth Mieko Furusho Pral, Pral, Elisabeth Mieko Furusho, Lisvane Silva Paes, Erich B Tahara, Flávia Menezes Zimbres, Brian Suárez Mantilla, Alicia J Kowaltowski, Zimbres Flávia Menezes, Pral Elisabeth Mieko Furusho, Tahara Erich B., Silber Ariel Mariano, Kowaltowski Alicia J., Suárez Mantilla Brian, Elias Maria Carolina, Diogo de Melo Patrícia, Paes Lisvane Silva   +26 more
core   +1 more source

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8

Brain Pathology, EarlyView.
We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren, Carola Hedberg‐Oldfors, Kittichate Visuttijai, Sara Nordström, Hans Goebel, Anders Oldfors   +5 more
wiley   +1 more source

Вміст вільного проліну при реалізації морфогенетичного потенціалу соняшника за Agrobacterium-опосередкованої трансформації

Фактори експериментальної еволюції організмів, 2014
Aim. Plant tissue totipotency – is the essential ability that is used in biotechnology. This peculiar feature responds to various changes of the total metabolism as well as fluctuations of some substances.
А. Г. Комісаренко, С. І. Михальська, Л. Є. Сергєєва, В. М. Курчій, О. М. Тищенко   +4 more
doaj  

Ornithine cyclodeaminase/μ-crystallin homolog from the hyperthermophilic archaeon Thermococcus litoralis functions as a novel Δ1-pyrroline-2-carboxylate reductase involved in putative trans-3-hydroxy-l-proline metabolism

FEBS Open Bio, 2014
l-Ornithine cyclodeaminase (OCD) is involved in l-proline biosynthesis and catalyzes the unique deaminating cyclization of l-ornithine to l-proline via a Δ1-pyrroline-2-carboxyrate (Pyr2C) intermediate.
Seiya Watanabe, Yuzuru Tozawa, Yasuo Watanabe   +2 more
doaj   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

The proline regulatory axis and cancer

Frontiers in Oncology, 2012
Studies in metabolism and cancer have characterized changes in core pathways involving glucose and glutamine, emphasizing the provision of substrates for building cell mass.
James Ming Phang
doaj   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source