Results 91 to 100 of about 47,460 (254)

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism [PDF]

, 2013
Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei ...
Mazet Muriel, Muriel Mazet, Scapozza, L., Brun Reto, Bakker, Barbara M.; id_orcid, Leonardo Scapozza (102177), Leonardo Scapozza, Bergamini Christian, Remo Perozzo, Federica Prati, Bakker Barbara M., Bergamini, C., Barbara M. Bakker, Haanstra, J.R.; id_orcid, Cavalli Andrea, Capranico, G., Bakker, B.M., Jurgen R Haanstra, Mazet, M., Bakker, Barbara M., Haanstra, J.R., Capranico, Giovanni, Pieretti, S., Giovanni Capranico (102150), Haanstra, Jurgen R., Lenaz Giorgio, Bakker, Barbara M, Romana Fato (102127), Jurgen R. Haanstra, Michels, Paulus, Jurgen R. Haanstra (102071), Andrea Cavalli, Perozzo, Remo, Bergamini, Christian, Bolognesi, M.L., Pieretti, Simone, Reto Brun, Reto Brun (41511), Brun, R., Bolognesi Maria Laura, Fato, Romana, Perozzo, R., Simone Pieretti, Andrea Cavalli (102196), Giovanni Capranico, Michels, Paul A. M., Lenaz, G., Christian Bergamini (102106), Paul A. M. Michels, Scapozza Leonardo, Remo Perozzo (102094), Haanstra, Jurgen R, Muriel Mazet (102083), Giorgio Lenaz, Giorgio Lenaz (102138), Fato, R., Prati, Federica, Maria Laura Bolognesi, Barbara M. Bakker (102159), Cavalli, Andrea, Paul A M Michels, Pieretti Simone, Barbara M Bakker, Lenaz, Giorgio, Perozzo Remo, Prati, F., Michels Paul A. M., Haanstra Jurgen R., Christian Bergamini, Fato Romana, Michels, P.A.M., Paul A. M. Michels (102168), Romana Fato, Brun, Reto, Bolognesi, Maria Laura, Cavalli, A., Mazet, Muriel, Scapozza, Leonardo, Simone Pieretti (102060), Prati Federica, Maria Laura Bolognesi (102185), Capranico Giovanni, Federica Prati (102117)   +82 more
core   +1 more source

Schematic representation of the proline metabolism pathway and the proline cycle.

, 2022
A) Most of the metabolism of proline is localized in the mitochondrion, although the PYCR3 enzyme is localized in the cytoplasm. The main precursors of proline are glutamine/glutamate and ornithine.
Rajinder Singh (246689), Jennifer A. Higgins (7641458), Lynsey Burke (12055056), Alessandro Rufini (3873532), Raquel Palacios-Gallego (12055065), Constantinos Alexandrou (7705007), Cristina Tufarelli (643585), Robert G. Britton (7596356), Saif Sattar Alaqbi (12055053), Caleb Green (12055062), Ni Ni Moe Myint (7787714), Inna Guterman (12055059), Lynne M. Howells (7583441), Donald J. L. Jones (7584767), Anne Thomas (90885), Kevin West (1353297), Hong Cai (166815), Emma Parrott (10646312)   +17 more
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Comparative analysis of physiological salt tolerance mechanisms for some Indian mustard varieties

RUDN Journal of Agronomy and Animal Industries, 2010
The comparison and assessment have been performed to characterize salt tolerance of some varieties of Indian mustard (Brassica juncea Czern.) seedlings and young plants.
A L Grinin, I A Korshunov, V P Kholodova, Vl V Kuznetsov   +3 more
doaj  

Drought Risk in Mango and Avocado Orchards: Insights Into Plant Water Relations and Irrigation‐Related Agronomic Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley   +1 more source

Archaeal proline dehydrogenase from Pyrobaculum aerophilum : sequence comparison.

, 2009
Based on the amino acid sequence, proline dehydrogenase from hyperthermophilic archaeon, Pyrobaculum aerophilum showed no significant homology with previously known bacterial proline dehydrogenase, as exemplified with Salmonella typhimurium and ...
Kik, Shian Chi.
core  

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Ornithine cyclodeaminase/μ-crystallin homolog from the hyperthermophilic archaeon Thermococcus litoralis functions as a novel Δ1-pyrroline-2-carboxylate reductase involved in putative trans-3-hydroxy-l-proline metabolism

FEBS Open Bio, 2014
l-Ornithine cyclodeaminase (OCD) is involved in l-proline biosynthesis and catalyzes the unique deaminating cyclization of l-ornithine to l-proline via a Δ1-pyrroline-2-carboxyrate (Pyr2C) intermediate.
Seiya Watanabe, Yuzuru Tozawa, Yasuo Watanabe   +2 more
doaj   +1 more source

increased catalase and peroxidase activities and proline content in Nitraria tangutorum callus

, 2012
Antioxidative responses and proline accumulation induced by exogenous H2O2 were investigated in the callus from halophyte Nitraria tangutorum Bobr. H2O2-treated callus exhibited higher H2O2 content than untreated callus.
H. Zhang, Y. Y. Zhang, R. X. Shi, Y. Jiang, Y. Liu, Y. L. Yang, J. Lu   +6 more
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source