Results 181 to 190 of about 88,584 (246)

Hydrophobic interactions of a substrate with L193 on the flexible substrate‐binding loop contribute to 3α‐hydroxysteroid dehydrogenase/carbonyl reductase catalytic efficiency

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Flexible loops within enzyme active sites are central to substrate binding, transition‐state stabilization, and catalytic turnover. Hydrophobic interactions modulate ligand recognition and influence protein function. Here, we interrogated loop‐mediated hydrophobic contributions to catalysis in 3α‐hydroxysteroid dehydrogenase/carbonyl reductase
Yan‐Liang Chen, Yun‐Hao Chou, Hwei‐Jen Lee, Tzu‐Pin Wang, Chi‐Ching Hwang   +4 more
wiley   +1 more source

Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. [PDF]

Mol Cancer Ther, 2019
Scott GK, Yau C, Becker BC, Khateeb S, Mahoney S, Jensen MB, Hann B, Cowen BJ, Pegan SD, Benz CC.   +9 more
europepmc   +1 more source

Advances in Wine Yeast Autolysis: Biochemical and Molecular Mechanisms, and the Release of Organic Compounds in White and Sparkling Wines—An Updated Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos, Aniela Pinto Kempka   +1 more
wiley   +1 more source

The C2H2‐GGAT Regulatory Module Fine‐Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3282-3295, May 2026.
ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su, Xiaojuan Yang, Chanyuan Wu, Xianyao Jin, Yuanyuan Zhang, Yuyan Zhang, Kunsong Chen, Mingliang Yu, Bo Zhang   +8 more
wiley   +1 more source

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot, Iván Lavandera, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence. [PDF]

Int J Mol Sci
Grossi S, Berno E, Chiofalo P, Chiaravalli AM, Cinquetti R, Bruno A, Palano MT, Gallazzi M, La Rosa S, Sessa F, Acquati F, Campomenosi P.   +11 more
europepmc   +1 more source

Proline dehydrogenase from Thermus thermophilus does not discriminate between FAD and FMN as cofactor. [PDF]

Sci Rep, 2017
Huijbers MM, Martínez-Júlvez M, Westphal AH, Delgado-Arciniega E, Medina M, van Berkel WJ.   +5 more
europepmc   +1 more source

Crystallization and preliminary crystallographic analysis of mannitol dehydrogenase (MtDH) from the common mushroom Agaricus bisporus [PDF]

, 2001
Baumann, U., Horer, S., Mooibroek, H., Sassoon, J., Stoop, J.   +4 more
core   +3 more sources

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. [PDF]

Amino Acids, 2016
Hancock CN, Liu W, Alvord WG, Phang JM.
europepmc   +1 more source

Erratum to: Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. [PDF]

Amino Acids, 2016
Hancock CN, Liu W, Gregory Alvord W, Phang JM.   +3 more
europepmc   +1 more source