Results 171 to 180 of about 251,378 (256)

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase. [PDF]

Arch Biochem Biophys
Meeks KR, Ji J, Scott GK, Campbell AC, Nix JC, Tadeo A, Ellerby LM, Benz CC, Tanner JJ.   +8 more
europepmc   +1 more source

Egg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A novel shad egg peptide (EP) significantly extends Caenorhabditis elegans lifespan through a dual antiaging mechanism. EP systematically remodels lipid metabolism to reinforce cell membranes by promoting beneficial fatty acid biosynthesis and suppressing degradation. Simultaneously, its potent antioxidant activity alleviates oxidative damage, shifting
Jia Du, Qinghua Liu, Zhongxiao Wan, Naomi Sudo, Yanyang Xu   +4 more
wiley   +1 more source

Cytotoxic Effects of Medicinal Plant Extracts on HeLa Cells via Redox Imbalance, L‐Arginine Metabolic Reprogramming, and Glycolytic Suppression

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Cancer cells undergo metabolic reprogramming to sustain proliferation, resist apoptosis, and adapt to oxidative stress. In the present study, we comparatively evaluated the anticancer effects of four medicinal plant extracts (Inula helenium, Hypericum alpestre, Rumex obtusifolius, and Alchemilla smirnovii) on HeLa cervical cancer cells, with ...
Mery Kocharyan, Gohar Sevoyan, Hasmik Karapetyan, Anzhela Sargsyan, Mikayel Ginovyan, Nikolay Avtandilyan, Hayarpi Javrushyan   +6 more
wiley   +1 more source

Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. [PDF]

Mol Cancer Ther, 2019
Scott GK, Yau C, Becker BC, Khateeb S, Mahoney S, Jensen MB, Hann B, Cowen BJ, Pegan SD, Benz CC.   +9 more
europepmc   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego, Giuseppina Andreotti, Maria Monticelli, Debora Paris, Arturo Martín‐Martínez, Alejandra Gámez, Mercedes Serrano, José Córdoba‐Caballero, Pedro Seoane, Juan A. G. Ranea, Belén Pérez   +10 more
wiley   +1 more source

Irritable Bowel Disease: Think Malonic and Methylmalonic Aciduria (CMAMMA)!

JIMD Reports, Volume 67, Issue 5, September 2026.
ABSTRACT Combined malonic and methylmalonic aciduria (CMAMMA; OMIM 614265) is a rare disorder of mitochondrial fatty acid synthesis caused by pathogenic variants in the ACSF3 gene, which encodes malonyl‐CoA synthetase. The clinical presentation is highly heterogeneous and may include seizures, memory impairment, psychiatric manifestations, and ...
Khaled Alatibi, Martin J. Hug, Sara Tucci   +2 more
wiley   +1 more source

A study on the importance of an intact-ring structure on proline racemase catalysis

, 2018
Proline racemase (PR) catalyses the interconversion of L-proline and D-proline, in a cofactor-independent manner. PR follows a two-base mechanism, using two Cys residues in the active site that act as enantiospecific Brønsted bases, to catalyse the ...
Srinivasan, Pooja
core  

Calcium, methyl jasmonate and their combined foliar applications: Influence on Tempranillo grape amino acids composition over two seasons

Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7380-7396, September 2026.
Abstract BACKGROUND Climate change is currently affecting chemical grape composition and, consequently, grape quality. The foliar application of biostimulants has emerged as a promising approach to mitigate these effects. This study investigated the effects of foliar applications of calcium (Ca), methyl jasmonate (MeJ), and their combination (Ca + MeJ)
Teresa Garde‐Cerdán, Eva P Pérez‐Álvarez, Itziar Sáenz de Urturi, Rebeca Murillo‐Peña, Lesly L Torres‐Díaz, Miriam González‐Lázaro   +5 more
wiley   +1 more source

Proline Dehydrogenase (PRODH) Is Expressed in Lung Adenocarcinoma and Modulates Cell Survival and 3D Growth by Inducing Cellular Senescence. [PDF]

Int J Mol Sci
Grossi S, Berno E, Chiofalo P, Chiaravalli AM, Cinquetti R, Bruno A, Palano MT, Gallazzi M, La Rosa S, Sessa F, Acquati F, Campomenosi P.   +11 more
europepmc   +1 more source