Results 51 to 60 of about 88,083 (193)

Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
core   +1 more source

Hydrogen Sulfide Treatment Alleviates Chilling Injury in Cucumber Fruit by Regulating Antioxidant Capacity, Energy Metabolism and Proline Metabolism

Foods, 2022
Although low-temperature storage could maintain the quality of fruits and vegetables, it may also result in chilling injury (CI) in cold-sensitive produce, such as cucumbers.
Jingda Wang, Yaqin Zhao, Zhiqian Ma, Yonghua Zheng, Peng Jin   +4 more
doaj   +1 more source

Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus [PDF]

Journal of Biological Chemistry, 2007
Proline dehydrogenase (PRODH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyze the two-step oxidation of proline to glutamate. They are distinct monofunctional enzymes in all eukaryotes and some bacteria but are fused into bifunctional enzymes known as proline utilization A (PutA) in other bacteria. Here we report the first structure
Tommi A, White, Navasona, Krishnan, Donald F, Becker, John J, Tanner   +3 more
openaire   +2 more sources

A bienzyme electrochemical biosensor for the detection of collagen l-hydroxyproline

Sensing and Bio-Sensing Research, 2015
l-hydroxyproline (l-Hyp: trans-4-hydroxy-l-proline) is commonly found at high concentrations in connective tissue proteins such as collagen. It is a remarkably useful molecular marker because variation in the level of l-Hyp is associated with various ...
Hiroaki Sakamoto, Kazuya Watanabe, Ayako Koto, Gaku Koizumi, Takenori Satomura, Seiya Watanabe, Shin-ichiro Suye   +6 more
doaj   +1 more source

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]

, 2015
Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core   +1 more source

Proline–Nitrogen Metabolic Coordination Mediates Cold Priming-Induced Freezing Tolerance in Maize

Plants
Cold stress critically restricts maize seedling growth in Northeast China, yet the mechanism by which cold priming (CP) enhances cold tolerance through proline–nitrogen metabolic networks remains unclear.
Zhijia Gai, Lei Liu, Na Zhang, Jingqi Liu, Lijun Cai, Xu Yang, Ao Zhang, Pengfei Zhang, Junjie Ding, Yifei Zhang   +9 more
doaj   +1 more source

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade

Cell Reports, 2016
Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders.
Gregg W. Crabtree, Alan J. Park, Joshua A. Gordon, Joseph A. Gogos   +3 more
doaj   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources

Gene regulatory networks elucidating huanglongbing disease mechanisms. [PDF]

, 2013
Next-generation sequencing was exploited to gain deeper insight into the response to infection by Candidatus liberibacter asiaticus (CaLas), especially the immune disregulation and metabolic dysfunction caused by source-sink disruption.
Albrecht, Ute, Bowman, Kim D, Dandekar, Abhaya M, Davis, Cristina E, Martinelli, Federico, Phu, My L, Reagan, Russell L, Uratsu, Sandra L, Zhao, Weixiang   +8 more
core   +9 more sources

The effect of water deficit and excess copper on proline metabolism in Nicotiana benthamiana

Biologia Plantarum, 2012
Fluctuation in proline content is a widespread phenomenon among plants in response to heavy metal stress. To distinguish between the participation of water deficit and copper on changes in proline metabolism, potted plants and floating leaf discs of ...
H. -M. Ku, C. -W. Tan, Y. -S. Su, C. -Y. Chiu, C. -T. Chen, F. -J. Jan   +5 more
doaj   +1 more source