Promyelocytic Leukemia Protein (PML) Controls
mBio, 2017 The promyelocytic leukemia protein (PML) is the main organizer of stress-responsive subnuclear structures called PML nuclear bodies. These structures recruit multiple interactors and modulate their abundance or their posttranslational modifications ...
David Ribet +6 more
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Promyelocytic leukemia protein targets MK2 to promote cytotoxicity. [PDF]
EMBO Rep, 2021 Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml−/− macrophages being more resistant to
Chen IT +7 more
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Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation. [PDF]
Mol Cell Proteomics, 2018 We report that interferon (IFN) α treatment at short and long periods increases the global cellular SUMOylation and requires the presence of the SUMO E3 ligase promyelocytic leukemia protein (PML), the organizer of PML nuclear bodies (NBs).
Maroui MA +5 more
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Characterization and functional analysis of chicken promyelocytic leukemia protein [PDF]
Poultry Science: In mammals, promyelocytic leukemia (PML) protein, also named as TRIM19, is the key component of nuclear membrane-less sub structures PML nuclear bodies (PML-NB) or nuclear domains 10 (ND10). PML-NBs are dynamic foci that consist of numerous permanently
Shengnan Wang +8 more
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Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1. [PDF]
PLoS Pathogens, 2020 Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are ...
Christina Paulus +6 more
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Cellular promyelocytic leukemia protein is an important dengue virus restriction factor. [PDF]
PLoS One, 2015 The intrinsic antiviral defense is based on cellular restriction factors that are constitutively expressed and, thus, active even before a pathogen enters the cell.
Giovannoni F, Damonte EB, García CC.
europepmc +7 more sources
Histone lactylation-boosted ALKBH3 potentiates tumor progression and diminished promyelocytic leukemia protein nuclear condensates by m1A demethylation of SP100A. [PDF]
Nucleic Acids Res, 2023 Albeit N1-Methyladenosine (m1A) RNA modification represents an important regulator of RNA metabolism, the role of m1A modification in carcinogenesis remains enigmatic.
Gu X +8 more
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Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides. [PDF]
PLoS ONE, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez +2 more
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Promyelocytic Leukemia Protein Is an Essential Regulator of Stem Cell Pluripotency and Somatic Cell Reprogramming. [PDF]
Stem Cell Reports, 2017 Summary Promyelocytic leukemia protein (PML), the main constituent of PML nuclear bodies, regulates various physiological processes in different cell types. However, little is known about its functions in embryonic stem cells (ESC).
Hadjimichael C +7 more
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Epstein - Barr virus latent membrane protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies [PDF]
Virology Journal, 2011 The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs).
Flemington Erik K +5 more
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