Results 101 to 110 of about 136,204 (260)

Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts

Cellular Physiology and Biochemistry, 2015
Background/Aims: Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute to the initiation of acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) upregulates expression of TGF-β1,
Wen-Xiao Xu, Sheng-Zhi Liu, Di Wu, Guo-Fen Qiao, Jinglong Yan   +4 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Case report: Germline RECQL mutation potentially involved in hereditary predisposition to acute leukemia

Frontiers in Oncology, 2023
The pathogenesis of acute leukemia is still complex and vague. Most types of acute leukemia are related to somatic gene mutations, and familial incidence is rare. Here we report a case of familial leukemia.
Wei Yuan, Zhen Shang, Zhen Shang, Kefeng Shen, Kefeng Shen, Qiuxia Yu, Qiuxia Yu, Qiuxia Lv, Qiuxia Lv, Yang Cao, Yang Cao, Jue Wang, Jue Wang, Yi Yang   +13 more
doaj   +1 more source

SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma [PDF]

, 2018
Our previous data supported a role for the Stearoyl-CoA desaturase (SCD5) in protection against malignancy, whereby it appears to functionally modify tumor stroma impairing tumor spread.
Bellenghi, Maria, Bottero, Lisabianca, Carè, Alessandra, Felicetti, Federica, Gulino, Alessandro, Mattia, Gianfranco, Petrini, Marina, Pontecorvi, Giada, Puglisi, Rossella   +8 more
core   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Retinoic acid-induced differentiation sensitizes myeloid progenitors cells to ER stress [PDF]

, 2017
The clonal expansion of hematopoietic myeloid precursors blocked at different stages of differentiation characterizes the acute myeloid leukemia (AML) phenotype.
Capuano, Ernestina, Fazi, Francesco, Francesco, Lo coco, Mariadomenica, Divona, Masciarelli, Silvia, Noguera, Nélida I., Simone De, Panfilis, Tiziana, Ottone   +7 more
core   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML.

PLoS ONE, 2014
Previously we reported that the expression of promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARα) fusion gene, which is caused by specific translocation (15;17) in acute promyelocytic leukemia, can enhance constitutive autophagic activity in
Wei He, Chuan-Xi Hu, Jia-Kai Hou, Li Fan, Yi-Wei Xu, Man-Hua Liu, Shu-Yang Yan, Guo-Qiang Chen, Ying Huang   +8 more
doaj   +1 more source

Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro [PDF]

, 2015
© 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing ...
Gizelska, Katarzyna, Hoffman, Ewelina A, Mielicki, Wojciech, Mirowski, Marek   +3 more
core   +2 more sources

Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells.

Virology, 2011
Promyelocytic leukemia protein nuclear bodies (PML NBs) have been implicated in host immune response to viral infection. PML NBs are targeted for degradation during reactivation of herpes viruses, suggesting that disruption of PML NB function supports ...
Mark D. Sides, Gregory J. Block, B. Shan, Kyle C. Esteves, Zhen Lin, E. Flemington, J. Lasky   +6 more
semanticscholar   +1 more source