Results 141 to 150 of about 136,204 (260)

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

Discordant Vitamin B12 Results in an IgA Nephropathy Patient

Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.
ABSTRACT Background Discordant Vitamin B12 results can result from immunoassay interferences, potentially leading to unnecessary diagnostic procedures and misdiagnoses if not properly recognized. Case Presentation A 76‐year‐old male with a history of IgA nephropathy, hypertension, and other comorbidities presented with unexpectedly elevated total ...
Oytun Portakal, Nazende Işlak, Muhammed Ş. Binici, Yahya Büyükaşik   +3 more
wiley   +1 more source

Porcine promyelocytic leukemia protein isoforms suppress Japanese encephalitis virus replication in PK15 cells. [PDF]

Virol J, 2023
Chen Z, Liu H, Zhu J, Duan X, Wang H, Li X, Zhou X, Zhao A, Yang S.   +8 more
europepmc   +1 more source

Promyelocytic Leukemia Protein Controls Cell Migration in Response to Hydrogen Peroxide and Insulin-like Growth Factor-1*

Journal of Biological Chemistry, 2010
Promyelocytic leukemia protein (PML) was originally identified as part of a chromosomal translocation that contributes to the development of acute promyelocytic leukemia (APL).
Erin L. Reineke, Yu Liu, H. Kao
semanticscholar   +1 more source

Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line

Marine Drugs, 2005
: Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 ...
Tadashi Kasahara, Yoshio Honma, Hisayoshi Kobayashi, Kyoko Akano, Michio Namikoshi, Taiko Oda   +5 more
doaj   +1 more source

An antiviral disulfide compound blocks interaction between arenavirus Z protein and cellular promyelocytic leukemia protein.

Biochemical and Biophysical Research Communications - BBRC, 2010
The promyelocytic leukemia protein (PML) forms nuclear bodies (NB) that can be redistributed by virus infection. In particular, lymphocytic choriomeningitis virus (LCMV) influences disruption of PML NB through the interaction of PML with the arenaviral Z
C. García, Ivan Topisirovic, M. Djavani, Katherine L. B. Borden, E. Damonte, M. Salvato   +5 more
semanticscholar   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Is PML a tumor suppressor?

Frontiers in Oncology, 2013
The role of the promyelocytic leukemia protein (PML) has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature.
Massimiliano eMazza, Pier Giuseppe ePelicci   +1 more
doaj   +1 more source

Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells. [PDF]

Mol Oncol, 2023
Vogiatzoglou AP, Spanou S, Sachini N, Drakos E, Nikolaou C, Makatounakis T, Kretsovali A, Papamatheakis J.   +7 more
europepmc   +1 more source

SUMO Interaction Motifs in Sizn1 Are Required for Promyelocytic Leukemia Protein Nuclear Body Localization and for Transcriptional Activation*

Journal of Biological Chemistry, 2009
Mutations in Sizn1 (Zcchc12), a novel transcriptional co-activator in the BMP signaling pathway, are associated with X-linked mental retardation. Previously, we demonstrated that Sizn1 positively modulates the BMP signal by interacting with Smad family ...
Ginam Cho, Youngshin Lim, J. Golden
semanticscholar   +1 more source