Results 11 to 20 of about 136,204 (260)
Promyelocytic leukemia protein in mesenchymal stem cells is essential for leukemia progression. [PDF]
Ann Hematol, 2018 The dynamic interactions between leukemic cells and cells resident within the bone marrow microenvironment are vital for leukemia progression. The lack of detailed knowledge about the cellular and molecular mechanisms involved in this cross-talk restricts the design of effective treatments. Guarnerio et al.
de Alvarenga EC +5 more
europepmc +5 more sources
Promyelocytic Leukemia Protein (PML) and Stem Cells: from cancer to pluripotency.
The International Journal of Developmental Biology, 2021 The promyelocytic leukemia protein (PML) is the core organizer of the cognate nuclear bodies (PML-NBs). Through physical interaction or modification of diverse protein clients, PML-NBs regulate a multitude of - often antithetical- biological processes ...
A. Vogiatzoglou +4 more
semanticscholar +3 more sources
The promyelocytic leukemia zinc finger protein (PLZF): two decades of molecular oncology [PDF]
Frontiers in Oncology, 2012 The promyelocytic leukemia zinc finger protein (PLZF), also known as Zbtb16 or Zfp145, was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with the RARA ...
Bandar Ali Suliman +3 more
doaj +3 more sources
Promyelocytic Leukemia Protein Potently Restricts Human Cytomegalovirus Infection in Endothelial Cells. [PDF]
Int J Mol Sci, 2022 PML nuclear bodies (PML-NBs) are dynamic macromolecular complexes that mediate intrinsic immunity against viruses of different families, including human cytomegalovirus (HCMV). Upon HCMV infection, PML-NBs target viral genomes entering the nucleus and restrict viral immediate–early gene expression by epigenetic silencing.
Seitz S +3 more
europepmc +3 more sources
Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies [PDF]
International Journal of Biological Sciences, 2009 The promyelocytic leukemia protein (PML) is involved in many cellular processes including cell cycle progression, DNA damage response, transcriptional regulation, viral infection, and apoptosis. These cellular activities often rely on the localization of
Erin L. Reineke, H. Kao
semanticscholar +3 more sources
Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression [PDF]
International Journal of Molecular Sciences, 2021 Promyelocytic leukemia (PML) protein is the core component of subnuclear structures called PML nuclear bodies that are known to play important roles in cell survival, DNA damage responses, and DNA repair. Fanconi anemia (FA) proteins are required for repairing interstrand DNA crosslinks (ICLs).
Anudari Munkhjargal +6 more
openaire +3 more sources
Cytometry Part A, 2012 AbstractAcute promyelocytic leukemia (APL) is a hematological emergency in which a rapid diagnosis is essential for early administration of appropriate therapy, including all‐trans retinoic acid before the onset of fatal coagulopathy. Currently, the following methodologies are widely used for rapid initial diagnosis of APL: 1) identification of ...
P. Mirabelli +10 more
semanticscholar +4 more sources
Transcriptional Repression by the Promyelocytic Leukemia Protein, PML [PDF]
Experimental Cell Research, 1997 Acute promyelocytic leukemia is characterized by the presence of a t(15; 17) chromosomal translocation which results in the expression of a chimeric gene product, PMLRAR alpha, consisting of an N-terminal-truncated retinoic acid receptor-alpha fused to a C-terminal-truncated PML.
S, Vallian +6 more
openaire +4 more sources
The Promyelocytic Leukemia Protein Represses A20-mediated Transcription [PDF]
Journal of Biological Chemistry, 2002 The promyelocytic leukemia (PML) protein is a tumor suppressor that is disrupted by the chromosomal translocation t(15;17), a consistent cytogenetic feature of acute promyelocytic leukemia. A role of PML in multiple pathways of apoptosis was conclusively demonstrated using PML(-/-) animal and cell culture models.
Wen-Shu, Wu +2 more
openaire +2 more sources
Acute promyelocytic leukemia. State of the art
Iatreia, 2021 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) that results from a balanced translocation between chromosomes 15 and 17, which involves the gene encoding the retinoic acid receptor alpha (RARA) on chromosome 17 and the ...
Leonardo Mejía-Buriticá +2 more
doaj +1 more source