PML nuclear body biogenesis and oligomerization-driven leukemogenesis
Blood Science, 2020 . PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1–2 μm.
Yuwen Li, Xiaodan Ma, Guoyu Meng
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Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report [PDF]
, 2016 Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be ...
Kuhn, Marcus +3 more
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Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity [PDF]
Immunity, 2009 Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. Here, we identified the promyelocytic leukemia zinc finger (PLZF) protein as a previously unrecognized component of the IFN response.
Xu D +9 more
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Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
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Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]
, 2016 Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
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Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells [PDF]
, 2019 In this work, we have exploited the unique properties of a chimeric archaeal-human ferritin to encapsulate, deliver and release cytochrome c and induce apoptosis in a myeloid leukemia cell line.
Baiocco, P. +8 more
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Haematologica, 2016 The PML/RARA fusion protein occurs as a result of the t(15;17) translocation in the acute promyelocytic leukemia subtype of human acute myeloid leukemia.
Karen Keeshan +9 more
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Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]
, 2009 Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo +37 more
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Promyelocytic Leukemia-Nuclear Body Proteins: Herpesvirus Enemies, Accomplices, or Both? [PDF]
Future Virology, 2008 The promyelocytic leukemia (PML) protein gathers other cellular proteins, such as Daxx and Sp100, to form subnuclear structures termed PML-nuclear bodies (PML-NBs) or ND10 domains. Many infecting viral genomes localize to PML-NBs, leading to speculation that these structures may represent the most efficient subnuclear location for viral replication ...
Ryan T, Saffert, Robert F, Kalejta
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B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
Nature Communications, 2019 Promyelocytic leukemia protein (PML) is the scaffolding protein that organizes PML nuclear bodies. Here the authors determine the crystal structure of a PML B1-box multimer and characterise the oligomerisation behaviour of the PML RBCC construct and show
Yuwen Li +12 more
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