Results 41 to 50 of about 136,204 (260)

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Blood Advances, 2018
: The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that Hhex maintains leukemia stem cell self-renewal by enabling ...
Jacob T. Jackson, Ashley P. Ng, Benjamin J. Shields, Sue Haupt, Ygal Haupt, Matthew P. McCormack   +5 more
doaj   +1 more source

A role for cytoplasmic PML in cellular resistance to viral infection. [PDF]

PLoS ONE, 2008
PML gene was discovered as a fusion partner with retinoic acid receptor (RAR) alpha in the t(15:17) chromosomal translocation associated with acute promyelocytic leukemia (APL).
Beth A McNally, Joanne Trgovcich, Gerd G Maul, Yang Liu, Pan Zheng   +4 more
doaj   +1 more source

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]

, 2002
HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca, CASTOLDI, GL, CUNEO, Antonio, DE ANGELI, C, DEL SENNO, Laura, GANDINI, D, LANZA, F, MANZATI, E, PANDOLFI, PP   +8 more
core   +1 more source

PML protein expression in hematopoietic and acute promyelocytic leukemia cells [PDF]

Blood, 1993
Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein. Yet, paradoxically, APL cells are exquisitely sensitive to retinoic acid (RA), as they terminally differentiate upon RA exposure.
M T, Daniel, M, Koken, O, Romagné, S, Barbey, A, Bazarbachi, M, Stadler, M C, Guillemin, L, Degos, C, Chomienne, H, de Thé   +9 more
openaire   +3 more sources

Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Life on Earth is constantly exposed to electromagnetic fields (EMFs) and the effects induced by EMFs on biological systems have been extensively studied producing different and sometimes contradictory results.
Alfredo Errico Provenzano, Stefano Amatori, Maria Gemma Nasoni, Giuseppe Persico, Sergio Russo, Anna Rita Mastrogiacomo, Alessandro Gambarara, Mirco Fanelli   +7 more
doaj   +1 more source

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. [PDF]

Molecular Endocrinology, 2014
The promyelocytic leukemia zinc finger (PLZF) protein is involved in major biological processes including energy metabolism, although its role remains unknown. In this study, we demonstrated that hepatic PLZF expression was induced in fasted or diabetic mice.
Siyu Chen, J. Qian, Xiaoli Shi, Tingting Gao, Tingming Liang, Chang Liu   +5 more
semanticscholar   +3 more sources

Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein [PDF]

International Journal of Cancer, 2009
AbstractThe promyelocytic leukemia zinc finger (PLZF) protein, a transcriptional repressor, induces cellular resistance to oncogenic transformation by diverse oncoproteins. Two point mutants of PLZF that have lost the antioncogenic activity of the wild‐type protein are oncogenic in chicken embryo fibroblasts; this activity is correlated with ...
Jin, Shi, Peter K, Vogt
openaire   +2 more sources

Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic

Journal of Pharmacological Sciences, 2014
.: Acute promyelocytic leukemia (APL) is characterized by the occurrence of translocations between chromosomes 15 and 17, resulting in generation of a fusion protein of promyelocytic leukemia (PML) and retinoid A receptor (RAR) α. APL cells are unable to
Takeaki Nitto, Kohei Sawaki
doaj   +1 more source