Results 51 to 60 of about 136,204 (260)
Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP. [PDF]
, 2013 Important insights into nuclear function would arise if gene loci physically interacting with particular subnuclear domains could be readily identified.
Ahmed, Kashif +4 more
core +2 more sources
Dysregulation of Promyelocytic Leukemia (PML) Protein Expression in Preeclamptic Placentae [PDF]
Reproductive Sciences, 2010 Promyelocytic leukemia (PML) protein is a nucleoprotein that can regulate a variety of cellular stress responses. The aim of this study was to determine qualitative and quantitative changes in PML expression in preeclamptic placentae. Immunoblot, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and immunohistochemistry techniques
Jonathan D, Leavenworth +6 more
openaire +2 more sources
RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Nature Communications, 2018 Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear ...
Pengran Wang +11 more
doaj +1 more source
Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. [PDF]
PLoS ONE, 2013 Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may
Yoshitaka Sunami +9 more
doaj +1 more source
Journal of Applied Hematology, 2022 Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia, which is highly aggressive, yet the most curable. It is a medical emergency that requires a very high index of suspicion, as delay in the treatment could lead to fatality.
Shipra Verma +3 more
doaj +1 more source
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Beech +34 more
core +4 more sources
PLoS Pathogens, 2015 Promyelocytic leukemia protein (PML), a major component of PML nuclear bodies (also known as nuclear domain 10), is involved in diverse cellular processes such as cell proliferation, apoptosis, gene regulation, and DNA damage response. PML also acts as a
Young-Eui Kim, Jin-Hyun Ahn
semanticscholar +1 more source
Cells, 2021 Calcium ions (Ca2+) play important and diverse roles in the regulation of autophagy, cell death and differentiation. Here, we investigated the impact of Ca2+ in regulating acute promyelocytic leukemia (APL) cell fate in response to the anti-cancer agent ...
Faten Merhi +9 more
doaj +1 more source
The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1 [PDF]
, 2014 The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence.
A Carracedo +33 more
core +1 more source
Molecular and Cellular Biology, 2015 To trigger type I interferon (IFN) responses, pattern recognition receptors activate signaling cascades that lead to transcription of IFN and IFN-stimulated genes (ISGs).
Yixiang Chen +3 more
semanticscholar +1 more source