Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein. [PDF]
PLoS ONE, 2014 Tetra-arsenic tetra-sulfide (As4S4) is an arsenic compound with anti-tumor activity, especially in acute promyelocytic leukemia (APL) that are resistant to retinoic acid (RA).
Yuwang Tian +10 more
doaj +1 more source
MORC3, a component of PML nuclear bodies, has a role in restricting herpes simplex virus type 1 and human cytomegalovirus [PDF]
, 2016 We previously reported that MORC3, a protein associated with promyelocytic leukemia nuclear bodies (PML NBs), is a target of HSV-1 ICP0 mediated degradation.
Everett, Roger +2 more
core +1 more source
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. [PDF]
Cancer Cell, 2010 BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function through phosphorylation. Furthermore, activated BMK1 notably inhibited PML-dependent activation of p21.
Qingkai Yang +8 more
semanticscholar +4 more sources
Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy
Frontiers in Immunology, 2018 The promyelocytic leukemia (PML) protein, also known as TRIM19, functions as a major organizer of PML nuclear bodies (NBs) in most mammalian cells and plays important roles in antiviral activities against both DNA and RNA viruses. In this study, we found
Deyan Chen +8 more
doaj +1 more source
The Tribble with APL: a new road to therapy [PDF]
, 2017 The t(15;17) translocation generates a PML-RARα fusion protein causative for acute promyelocytic leukemia (APL). Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disease progression and therapy resistance ...
Carmody, Ruaidhri, Keeshan, Karen
core +1 more source
1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. [PDF]
, 1984 The human-derived promyelocytic leukemia cell line, HL-60, is known to differentiate into mature myeloid cells in the presence of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3).
Donaldson, CA +5 more
core +1 more source
Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia
Molecular & Cellular Oncology, 2017 Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein α (C/EBPα) and inhibiting myeloid differentiation.
Ke Li, Feng Wang, Zhuo-Wei Hu
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: ASC is the common adaptor of caspase-1 activation in several inflammasomes. Results: A novel interaction between PML and ASC is identified. PML-deficient macrophages display enhanced levels of IL-1β secretion and higher levels of ASC in the ...
J. Dowling +8 more
semanticscholar +1 more source
Tumor suppressor function of Gata2 in Acute Promyelocytic Leukemia.
Blood, 2021 Most patients with acute promyelocytic leukemia (APL) can be cured with combined All Trans Retinoic Acid (ATRA) and Arsenic Trioxide therapy, which induce the destruction of PML-RARA, the initiating fusion protein for this disease1.
Casey D. S. Katerndahl +11 more
semanticscholar +1 more source
Hematology ReportsAcute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the ...
Sara Frazzetto +16 more
doaj +1 more source