Results 61 to 70 of about 19,002 (275)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Proopiomelanocortin Gene Product Regulation in Keratinocytes

Journal of Investigative Dermatology, 1996
Proopiomelanocortin (POMC) is the precursor for adrenocorticotropic hormone, melanocyte-stimulating hormones, beta-lipotropic hormone (beta LPH), and beta endorphin. These peptides can function as neurotransmitters, modulate immune responses, and affect melanogenesis. We investigated POMC expression and protein processing in normal human keratinocytes.
Wintzen, Marjolein, Yaar, Mina, Burbach, J. Peter H., Gilchrest, Barbara A.   +3 more
openaire   +2 more sources

The role of proopiomelanocortin (POMC) neurones in feeding behaviour

Nutrition & Metabolism, 2007
The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin.
Millington George WM
doaj   +1 more source

The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

Critical Care, 2021
Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely
Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe   +6 more
doaj   +1 more source

Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats [PDF]

, 2016
Specialized metabolic-sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counter regulatory responses.
Evans, ML, Fielding, B, Heisler, LK, Hurst, P, Lyons, D, Markkula, SP, Riches, C, Yueh, C-Y   +7 more
core   +2 more sources

SemaGBA: A System Dynamics Model of the Semaglutide‐Responsive Gut‐Brain Axis A Model of How the Brain and Semaglutide Regulate Appetite and Weight

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5184-5194, June 2026.
ABSTRACT Aims Semaglutide is a GLP‐1 receptor agonist for the treatment of type 2 diabetes and obesity. Its clinical effects are well established, but the underlying mechanisms remain unclear. This study aims to use computational modelling to generate hypotheses about semaglutide's long‐term metabolic (body weight, net energy intake, blood glucose ...
Vivan C. W. Kennis, Natal A. W. van Riel
wiley   +1 more source

The human adrenal cortex: growth control and disorders

Clinics, 2018
This review summarizes key knowledge regarding the development, growth, and growth disorders of the adrenal cortex from a molecular perspective. The adrenal gland consists of two distinct regions: the cortex and the medulla.
Claudimara Ferini Pacicco Lotfi, Jean Lucas Kremer, Barbara dos Santos Passaia, Isadora Pontes Cavalcante   +3 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. [PDF]

, 1990
Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that ...
Barr, P, Brake, A, Bresnahan, P, Gibson, H, Leduc, R, Thomas, G, Thomas, L, THORNER, Jeremy W.   +7 more
core   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source