Results 71 to 80 of about 11,890 (215)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Ultraviolet B Irradiation of the Eye Activates a Nitric Oxide-dependent Hypothalamopituitary Proopiomelanocortin Pathway and Modulates Functions of α-Melanocyte-stimulating Hormone-responsive Cells

, 2003
Ultraviolet B radiation increases DOPA-positive melanocytes in the skin specifically at the site of exposure. We found unexpectedly that ultraviolet B irradiation of the eye increased the concentration of α-melanocyte-stimulating hormone in plasma and ...
Inoue, Masayasu, Yanagihara, Nobuyo, Hiramoto, Keiichi, Sato, Eisuke F.   +3 more
core   +1 more source

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Cloning of sole proopiomelanocortin (POMC) cDNA and the effects of stocking density on POMC mRNA and growth rate in sole, Solea solea

, 2008
Proopiomelanocortin (POMC) is an important gene implicated in different functions, such as the stress response of the hypothalamus– pituitary–adrenal axis.
POLZONETTI MAGNI AM, MOSCONI G, NABISSI M, TIBALDI, Emilio, CARDINALETTI, Gloriana, PALERMO F   +5 more
core   +2 more sources

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Molecular Metabolism, 2020
Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli, Jordi Altirriba, Arnaud Obri, Elena Eyre Sánchez, Iñigo Chivite, Maria Milà-Guasch, Sara Ramírez, Alicia G. Gómez-Valadés, Macarena Pozo, Jasmine Burguet, Licio A. Velloso, Marc Claret   +11 more
doaj   +1 more source

Coat Color‐Associated Transcriptomic Differences of Black and White Hortobágyi Racka Sheep Using the RNA‐Seq Technique

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared skin transcriptomes of black‐ and white‐coated Hortobágyi Racka sheep using RNA‐seq to identify coat color‐associated molecular differences. Black‐coated sheep showed coordinated upregulation of melanogenesis and melanosome‐related genes together with pathways linked to redox balance, mitochondrial metabolism, and thermogenesis.
Putri Kusuma Astuti, Zoltán Bagi, Lilla Bodrogi, Szilvia Kusza   +3 more
wiley   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

NÖRON HÜCRELERİNDE ILE22MET PROOPİOMELANOCORTİN MUTASYONUNUN HÜCRESEL MEKANİZMASININ İNCELENMESİ

, 2017
NÖRON HÜCRELERİNDE ILE22MET PROOPİOMELANOCORTİN MUTASYONUNUN HÜCRESEL MEKANİZMASININ ...
Vural, Merve, Yanık, Tülin
core