Results 91 to 100 of about 19,002 (275)

Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

Molecular Metabolism, 2020
Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms
Roberta Haddad-Tóvolli, Jordi Altirriba, Arnaud Obri, Elena Eyre Sánchez, Iñigo Chivite, Maria Milà-Guasch, Sara Ramírez, Alicia G. Gómez-Valadés, Macarena Pozo, Jasmine Burguet, Licio A. Velloso, Marc Claret   +11 more
doaj   +1 more source

Islet-1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood [PDF]

, 2015
Food intake and body weight regulation depend on proper expression of the proopiomelanocortin gene (Pomc) in a group of neurons located in the mediobasal hypothalamus of all vertebrates.
Gonzalez, Laura Elisabeth, Low, Malcolm J., Nasif, Sofia, Orquera, Daniela Paula, Rubinstein, Marcelo, Silva Junqueira de Souza, Flavio, Yamashita, Miho   +6 more
core   +2 more sources

The Impact of GLP‐1 Receptor Agonists on Esophagogastroduodenoscopy Outcomes: A Retrospective Cohort Study in a Predominantly African American Population

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) improve glycemic control and promote weight loss but may increase gastric residue, raising concerns during esophagogastroduodenoscopy (EGD). African American patients remain underrepresented in research on these agents.
Ahmed El Sabagh, Ahmad Abdulraheem, Ariel Jimenez, Bara Abujaber, Usman Afzal, Ghaith Almhanni, Kiandokht Bashiri, Islam Badr Ezzeldin Mohamed, Nehal Abdelbaky, Dania Qarkash, Valeria Londono, Anna Stephan, Serenity G. Budd, Alireza Meighani   +13 more
wiley   +1 more source

Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons

eLife, 2017
POMC neurons integrate metabolic signals from the periphery. Here, we show in mice that food deprivation induces a linear current-voltage relationship of AMPAR-mediated excitatory postsynaptic currents (EPSCs) in POMC neurons.
Shigetomo Suyama, Alexandra Ralevski, Zhong-Wu Liu, Marcelo O Dietrich, Toshihiko Yada, Stephanie E Simonds, Michael A Cowley, Xiao-Bing Gao, Sabrina Diano, Tamas L Horvath   +9 more
doaj   +1 more source

Six novel mutations in the proopiomelanocortin and melanocortin receptor 4 genes in severely obese adults living in southern Italy. [PDF]

, 2005
BACKGROUND: The genetic characterization of obese individuals could clarify the molecular mechanisms underlying body weight regulation and lead to targeted therapy.
Buono P, Capone S, Contaldo F, Finelli C, Ieno L, Liguori R, Nardelli C, Oriani G, Pasanisi F, Sacchetti L   +9 more
core   +1 more source

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

eLife, 2018
Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype.
Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret   +3 more
doaj   +1 more source

Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling [PDF]

, 2017
In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived peptide α–melanocytestimulating hormone (α-MSH) promote satiety. POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A receptor type
Buono, Lorena, Cristino, Luigia, Morello, Giovanna   +2 more
core   +1 more source

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4437-4441, June 2026.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Pharmacokinetics and adverse effects of a long‐acting IM dopamine agonist: Cabergoline in healthy horses

Equine Veterinary Education, Volume 38, Issue 3, Page e170-e179, March 2026.
Summary Background Pituitary pars intermedia dysfunction (PPID) is commonly treated with pergolide mesylate, a dopamine receptor agonist. Cabergoline is a dopamine receptor agonist that has shown activity on prolactin secretion in horses for up to 10 days.
H. Hess, A. Bracken, S. Rao, Y. Nout‐Lomas, D. Gustafson, L. Bass   +5 more
wiley   +1 more source

Appropriate Inhibition of Orexigenic Hypothalamic Arcuate Nucleus Neurons Independently of Leptin Receptor/STAT3 Signaling [PDF]

, 2007
Leptin directly suppresses the activity of orexigenic neurons in the hypothalamic arcuate nucleus (ARC). We examined c-Fos-like immunoreactivity (CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin ...
Bates, Sarah H., Björnholm, Marie, Cowley, Michael A., Elmquist, Joel, Jobst, Erin E., Jones, Justin, Leshan, Rebecca, Myers, Martin G., Jr., Münzberg, Heiki, Sleeman, Mark, Villanueva, Eneida   +10 more
core   +2 more sources