Results 101 to 110 of about 11,890 (215)

中华鲟阿黑皮素原cDNA序列克隆及其序列分析

, 2011
通过构建中华鲟（Acipenser sinensis）垂体的SMART cDNA质粒文库,首次从文库中筛选得到阿黑皮素原（Proopiomelanocortin,POMC）cDNA全长序列,分别为阿黑皮素原A型基因（Proopiomelanocortin I,AsPOMC-A,EV824935）和阿黑皮素原B型基因（Proopiomelanocortin II,AsPOMC-B,EV825368）。其中,AsPOMC-A和AsPOMC-B分别在文库中出现128次和19次。AsPOMC-A全长1122 ...
危起伟, 桂建芳, 曹宏, 李创举
core   +2 more sources

Generation of an isogenic iPSC line via CRISPR correction of the POMC:W84X mutation for monogenic obesity modeling

Stem Cell Research
We report the generation of a genetically corrected induced pluripotent stem cell (iPSC) line, BIHi261-A-1, derived from the patient-specific iPSC line BIHi261-A carrying a homozygous truncating mutation in the POMC gene (POMC:W84X). This mutation causes
Katarzyna A. Ludwik, Valeria Fernandez Valone, Regina Jahn, Sabine Jyrch, Lara Lechner, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor

, 2006
Ciliary neurotrophic factor (CNTF) exerts anorectic effects by overcoming leptin resistance via activation of hypothalamic neurons. However, the exact site of CNTF action in the hypothalamus has not yet been identified.
Shanabrough, Marya, Horvath, Tamas L., Koch, Linda, Plum, Leona, Brüning, Jens C., Müller, Werner; id_orcid, Janoschek, Ruth, Münzberg, Heike, Diano, Sabrina   +8 more
core   +1 more source

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

, 2009
Recent studies demonstrated a role for hypothalamic insulin and leptin action in the regulation of glucose homeostasis. This regulation involves proopiomelanocortin (POMC) neurons because suppression of phosphatidyl inositol 3-kinase (PI3K) signaling in ...
Elmquist, J.K., Cho, You-Ree, Elmquist, Joel K., Zhao, J.J., Luo, Ji, Fukuda, M., Cantley, Lewis C., Coppari, R, Luo, J., Cantley, LC, Coppari, R., Cantley, L.C., Coppari, Roberto, Preitner, F, Zhao, JJ, Kahn, Barbara B., Kahn, B.B., Preitner, F., Fukuda, Makota, Balthasar, N., Zhao, Jean J., Xu, Yong, Preitner, Frederic, Hill, J.W., Luo, J, Xu, Y, Balthasar, N, Hill, Jennifer W., Xu, Y., Fukuda, M, Hill, JW, Elmquist, JK, Balthasar, Nina, Cho, Y.R., Cho, YR, Kahn, BB   +35 more
core   +1 more source

Electroacupuncture reduces obesity by improving metabolism and up-regulating expression of hypothalamic Sirtuin 1 and proopiomelanocortin in obese rats

针刺研究, 2019
Objective To observe the effect of electroacupuncture(EA)on expression of hypothalamic sirtuin 1(SIRT1)and proopiomelanocortin(POMC),and body weight,food-intake,blood glucose,and blood lipid levels in obese rats,so as to explore its mechanisms underlying
HUANG Qi, CHEN Rui, CHEN Li, LIANG Feng-xia, HE Wen-juan, PENG Miao, LI Lun   +6 more
doaj   +2 more sources

Unexpected clinical features in a female patient with proopiomelanocortin (POMC) deficiency

, 2015
Background/aims: Loss of function mutations of proopiomelanocortin (POMC) gene results in adrenal insufficiency, early-onset hyperphagic obesity, and red hair. However, neuromotor retardation with POMC deficiency has not been reported before. Case report:
Darcan, Sukran, Goksen, Damla, Ucar, Sema Kalkan, Ozen, Samim, Ozcan, Nurhan   +4 more
core   +1 more source

Multiple sequence alignment

, 2011
Nexus file containing multiple sequence alignment for phylogenetic analysis of Flectonotus and Fritziana, with character sets defined for mitochondrial 16S ribosomal RNA and proopiomelanocortin A (POMC ...
Blackburn, David C., David C. Blackburn (244228)   +1 more
core   +1 more source

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +1 more source

Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability

Endocrinology, Diabetes & Metabolism Case Reports
A 52-year-old female patient with breast cancer presented with a history of fatigue and malaise 1 year prior. She was diagnosed with isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) on endocrinological examination.
Shin Urai, Hironori Bando, Mei Nakatsuji, Masaaki Yamamoto, Hidenori Fukuoka, Genzo Iguchi, Wataru Ogawa   +6 more
doaj   +1 more source

Angiotensin-(1-7) Activates Proopiomelanocortin Neurons in the Arcuate Nucleus. [PDF]

Hypertension
Vernail VL, Mehay DL, Kimbark KD, Tanner JA, Bingaman SS, Silberman Y, Arnold AC.   +6 more
europepmc   +1 more source