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The Proopiomelanocortin System
Annals of the New York Academy of Sciences, 1999ABSTRACT: POMC (31,000 MW) is localized to the pituitary, brain, skin, and other peripheral sites. The particular enzyme profile present within a cell dictates the nature of the hormonal ligand (melanocortin) synthesized and secreted: melanotropic peptides (α‐MSH β‐lipotropin, λ‐MSH), corticotropin (ACTH), several endorphins (e.g., met‐enkephalin ...
M E, Hadley, C, Haskell-Luevano
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Proopiomelanocortin Peptides and Sebogenesis
Annals of the New York Academy of Sciences, 2003Abstract: Previous animal studies have demonstrated that α‐melanocyte‐stimulating hormone (α‐MSH) is a sebotropic hormone in rats and that targeted disruption of melanocortin 5 receptor (MC5‐R) can down‐regulate sebum output in mice. To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and ...
Li, Zhang +4 more
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Evolutionary significance of proopiomelanocortin in agnatha and chondrichthyes
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2001Akiyoshi Takahashi +2 more
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Mutations in the Human Proopiomelanocortin Gene
Annals of the New York Academy of Sciences, 2003Abstract: The melanocortin peptides and their receptors represent one of the most complex systems in human endocrinology. Hormonal regulation includes pigmentation, weight maintenance, adrenal function, and exocrine gland secretion via endocrine, paracrine, autocrine, and neurocrine action of melanocortin peptides at five different but homologous ...
Heiko, Krude +2 more
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