Results 131 to 140 of about 8,881 (183)
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Trends in the evolution of the proopiomelanocortin gene
General and Comparative Endocrinology, 2005The POMC gene is perhaps the most extensively studied member of the opioid/orphanin gene family. In Phylum Chordata this gene has been characterized in representatives of every class within the Gnathostomata, as well as in one representative agnathan vertebrate, the marine lamprey.
Robert M, Dores, Stephanie, Lecaude
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Glucocorticoid Regulation of Hypothalamic Proopiomelanocortin
Neuroendocrinology, 1998Although glucocorticoids clearly inhibit proopiomelanocortin (POMC) gene transcription and peptide synthesis in the anterior pituitary, the effects of glucocorticoids on POMC in the hypothalamus are still unclear, even though most POMC neurons in the arcuate nucleus are known to have glucocorticoid receptors.
S L, Wardlaw +2 more
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The Journal of Immunology, 1997
Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Abstract This report establishes the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon tessulatum.
M, Salzet +7 more
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Proopiomelanocortin-Derived Peptides
Endocrinology and Metabolism Clinics of North America, 1994Cloning of the cDNA of POMC mRNA led to the characterization of the ACTH precursor and established the molecular links between ACTH, beta LPH and gamma LPH, and beta end. Further previously unidentified POMC-derived peptides were also unravelled, including the N-terminal fragment and the JP.
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Synthesis and Glycosylation of Proopiomelanocortin by a Cushing Tumor*
The Journal of Clinical Endocrinology & Metabolism, 1982ACTH derives from a larger protein, proopiomelanocortin (POMC), which is also the precursor to lipotropin, endorphin, melanotropin, and other peptides. The sequence of steps by which POMC is processed to ACTH has been delineated in detail in cultured mouse tumor cells, but little is known about these steps in human pituitary adenomas.
W L, Miller, L K, Johnson
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1987
Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Proopiomelanocortin (POMC) is the name given to the protein precursor for both s-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same ...
Michael Uhler, Edward Herbert
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Regulation of Testicular Proopiomelanocortin Gene Expression*
Endocrinology, 1987The POMC gene is expressed in testicular Leydig cells, but its mRNA is about 150-200 nucleotides shorter in these cells than in the pituitary. For this reason this testicular mRNA has been termed POMC-like mRNA. The purpose of the present study was to define the ontogeny and regulation of POMC gene expression in rat testis.
C L, Chen, M B, Madigan
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Regulation of Proopiomelanocortin Gene Expression in Pituitary
Endocrine Reviews, 1988I. Introduction THE POMC gene encodes the complex precursor to a variety of biologically active, important neuromodulator and endocrine peptides. It is expressed in a variety of tissues in the mammal, but its main site of expression is the pituitary anterior lobe cortocotroph and intermediate lobe melanotroph.
J R, Lundblad, J L, Roberts
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Pituitary Proopiomelanocortin Peptides in Mental Disorders
1986Publisher Summary Proopiomelanocortin (POMC) is a long-chain pituitary peptide (PP), the secretion of which is controlled by hypothalamic corticotropin-releasing factor (CRF). POMC is cleaved in the anterior pituitary (AP) into various fragments, including ACTH, β-lipotropin (β-LPH) and β-endorphin (β-E), which under physiological conditions are ...
F. Brambilla +4 more
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Proopiomelanocortin and the Immune‐Neuroendocrine Connection
Annals of the New York Academy of Sciences, 1999ABSTRACT:This presentation will cover the history, recent developments in, and implications of the ability of both the immune and neuroendocrine systems to produce POMC. The discovery of POMC in immune cells was one of the events that heralded a molecular understanding of neuroimmunomodulation.
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