Results 81 to 90 of about 11,905 (245)

CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 1, January-March 2025.
Abstract INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline, reduced brain volume and myelin loss, and increased brain functional connectivity.
Mihály Hajós, Kiran Pandey, Annabelle C. Singer, Duc Duong, Sara Bitarafan, Monika Shpokayte, Zach Malchano, Ralph Kern, James J. Lah, Allan I. Levey, Nicholas T. Seyfried   +10 more
wiley   +1 more source

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

Nature Communications, 2016
Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang, Fan Liu, Vojtech Franc, Liem Andhyk Halim, Huub Schellekens, Albert J. R. Heck   +5 more
doaj   +1 more source

The Emerging Clinical Usefulness of Complement Measurements [PDF]

, 1977
Not many years ago the main purpose of “complement” seemed to be to drill holes in sheep erythrocytes. In the classic experiment which was part of every medical student’s microbiology laboratory experience, a magic stuff called complement, somewhat ...
Ruddy, Shaun
core   +1 more source

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]

, 2018
BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R, Chanová, Marta, Craik, Charles S, Dvořák, Jan, Fajtová, Pavla, Horn, Martin, Hubálek, Martin, Jiang, Zhenze, Leontovyč, Adrian, Mareš, Michael, Marešová, Lucie, O'Donoghue, Anthony J, Ulrychová, Lenka, Vondrášek, Jiří   +13 more
core   +3 more sources

Complement‐targeted therapeutics: Are we there yet, or just getting started?

European Journal of Immunology, Volume 54, Issue 12, December 2024.
After a hesitant start, the number of available therapeutics that target the human complement system has surged from one to a dozen drugs in less than 20 years. Meanwhile, the clinical arsenal encompasses treatment modalities directed to several targets for the therapy of a steadily growing spectrum of complement‐related disorders. Abstract Therapeutic
Daniel Ricklin
wiley   +1 more source

Widely Used Commercial ELISA Does Not Detect Precursor of Haptoglobin2, but Recognizes Properdin as a Potential Second Member of the Zonulin Family

Frontiers in Endocrinology, 2018
BackgroundThere is increasing evidence for the role of impaired intestinal permeability in obesity and associated metabolic diseases. Zonulin is an established serum marker for intestinal permeability and identical to pre-haptoglobin2.
Lucas Scheffler, Alyce Crane, Henrike Heyne, Anke Tönjes, Dorit Schleinitz, Christian H. Ihling, Michael Stumvoll, Rachel Freire, Maria Fiorentino, Alessio Fasano, Peter Kovacs, John T. Heiker   +11 more
doaj   +1 more source

Decreased sialylation elicits complement‐related microglia response and bipolar cell loss in the mouse retina

Glia, Volume 72, Issue 12, Page 2295-2312, December 2024.
Main Points Hyposialylation in Gne+/‐ mice induced loss of retinal rod bipolar cells. Hyposialylation triggered complement, inflammation and apoptosis transcriptome pathways in the retina. Crossing Gne+/‐ with C3‐deficient mice prevented the retinal changes.
German Cuevas‐Rios, Tawfik Abou Assale, Jannis Wissfeld, Annemarie Bungartz, Julia Hofmann, Thomas Langmann, Harald Neumann   +6 more
wiley   +1 more source

Complement system biomarkers in first episode psychosis [PDF]

, 2019
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta, Gaughran, Fiona, Kopczynska, Maja, Mondelli, Valeria, Morgan, B. Paul, Murray, Robin, O'Donovan, Michael, Touchard, Samuel, Zelek, Wioleta   +8 more
core   +2 more sources

The Properdin System: Composition and Function [PDF]

Vox Sanguinis, 1978
Abstract.This article summarizes the physicochemical data on the factors which compose the properdin system in guinea pig and man. The following other topics are discussed: (1) Activation of the properdin system; (2) Formation of the initiating and amplification C3 convertases; (3) Formation of the C5 convertase, and (4) Regulatory control mechanisms ...
openaire   +3 more sources

Case report: A novel high‐dose intravenous immunoglobulin preparation for the treatment of severe pemphigus vulgaris failing standard therapy

The Journal of Dermatology, Volume 51, Issue 12, Page 1665-1668, December 2024.
Abstract Pemphigus vulgaris (PV) is a severe autoimmune bullous dermatosis that is characterized by autoantibodies against epidermal adhesion proteins causing painful mucosal and skin blistering. Standard treatments for PV include corticosteroids, steroid‐sparing immunosuppressants, or intravenous monoclonal anti–CD20‐antibody therapy.
Nadine Wiedenmayer, Katharina Hogrefe, Silvia Mihalceanu, Julia K. Winkler, Alexander H. Enk   +4 more
wiley   +1 more source