Results 161 to 170 of about 3,425 (209)
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Clinical and Experimental Hypertension, 1987
We review here recent evidence that the ovaries synthesize and secrete prorenin and we explore the possible reasons why prorenin, and not active renin, is formed almost exclusively in this extra-renal site. Very high concentrations of prorenin are present in the human ovary in the fluid inside mature follicles.
N Glorioso, J E Sealey, Steven A Atlas
exaly +3 more sources
We review here recent evidence that the ovaries synthesize and secrete prorenin and we explore the possible reasons why prorenin, and not active renin, is formed almost exclusively in this extra-renal site. Very high concentrations of prorenin are present in the human ovary in the fluid inside mature follicles.
N Glorioso, J E Sealey, Steven A Atlas
exaly +3 more sources
Canadian Journal of Physiology and Pharmacology, 1991 After the discovery of an inactive, putative renin precursor that could be proteolytically activated, and the proteases involved in vivo, Morris and co-workers directly demonstrated that renin is indeed synthesized as a "pro" form, and from genetic coding sequences they provided the structure of human prorenin.
B J, Morris, D L, Smith
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Observations on the renal processing and sorting of prorenin
Canadian Journal of Physiology and Pharmacology, 1991 Human prorenin is the biosynthetic precursor of renin. In general, prorenin is enzymatically inactive until it is converted to renin. The kidney is the major source of renin in the circulation, and is also an important source of circulating prorenin.
W A, Hsueh, Y S, Do, P H, Wang
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Trends in Endocrinology & Metabolism, 1992
A rise in plasma prorenin often precedes the onset of vascular injury in patients with diabetes mellitus. Plasma prorenin measurements may be useful for predicting which patients will develop vascular injury and for monitoring the progression of the disease.
J M, Halimi, J E, Sealey
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A rise in plasma prorenin often precedes the onset of vascular injury in patients with diabetes mellitus. Plasma prorenin measurements may be useful for predicting which patients will develop vascular injury and for monitoring the progression of the disease.
J M, Halimi, J E, Sealey
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Do prorenin-synthesizing cells release active, ‘open’ prorenin?
Journal of Hypertension, 2017The function of prorenin, the inactive precursor of renin, remains unclear after many decades of research. The discovery of a (pro)renin receptor suggested that prorenin, by binding to this receptor, would become active, that is, obtain an 'open' conformation.
Martini, Alexandre +4 more
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Journal of Protein Chemistry, 1991
Using highly purified recombinant human prorenin, we report the first evidence for the formation of a stable, partially active, conformational variant of the recombinant proenzyme. The enzymatically active prorenin exhibits the following characteristics: (1) the proenzyme N-terminal sequence and molecular weight are maintained; (2) the active proenzyme
R, Edalji, T F, Holzman, E J, Gubbins
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Using highly purified recombinant human prorenin, we report the first evidence for the formation of a stable, partially active, conformational variant of the recombinant proenzyme. The enzymatically active prorenin exhibits the following characteristics: (1) the proenzyme N-terminal sequence and molecular weight are maintained; (2) the active proenzyme
R, Edalji, T F, Holzman, E J, Gubbins
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Prorenin Levels in Retinopathy of Prematurity
American Journal of Ophthalmology, 2007To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP).Noncomparative retrospective case control study.Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay.The mean prorenin concentrations were higher in preterm ...
Harumasa, Yokota +8 more
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1984
In the first report of activatable renin in 1971, Lumbers raised a question concerning the nature of the substance in human amniotic fluid, which showed marked increase in renin-like activity upon prolonged dialysis at pH 3.3 [1]. Since untreated amniotic fluid already showed a finite level of renin-like activity, at least three possible mechanisms ...
Tadashi Inagami +3 more
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In the first report of activatable renin in 1971, Lumbers raised a question concerning the nature of the substance in human amniotic fluid, which showed marked increase in renin-like activity upon prolonged dialysis at pH 3.3 [1]. Since untreated amniotic fluid already showed a finite level of renin-like activity, at least three possible mechanisms ...
Tadashi Inagami +3 more
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Prorenin and Vascular Complications of Diabetes
American Journal of Hypertension, 1989A high plasma prorenin is a marker of microvascular complications of diabetes. We have followed 56 adults and 120 children with uncomplicated insulin-dependent (type 1) diabetes. When plasma prorenin rises above the normal range in an adolescent or adult with type 1 diabetes, signs of nephropathy, retinopathy, or neuropathy follow within one to two ...
J A, Luetscher +2 more
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Podocytes as a Target of Prorenin in Diabetes
Current Diabetes Reviews, 2011High plasma prorenin levels predict the onset of microvascular complications, such as albuminuria/proteinuria,in diabetic patients. In diabetic rats with elevated plasma prorenin levels, treatment with HRP, which competitively inhibits the binding of prorenin to the (pro)renin receptor [(P)RR] as a decoy peptide, significantly prevented the development
Mariyo, Sakoda +2 more
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