Results 111 to 120 of about 3,781 (209)

The Docosatriene Protectin D1 Is Produced by T H 2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

, 2019
Docosahexaenoic acid, a major omega-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated.
Li, Pin-Lan, Wang, Wei, Ariel, Amiram, Gotlinger, Katherine H., Fredman, Gabrielle, Tang, Wang-Xian, Serhan, Charles N., Hong, Song   +7 more
core   +1 more source

Overexpression of protectin (CD59) down-modulates the susceptibility of human melanoma cells to homologous complement

, 2000
The clinical efficacy of therapeutic complement (C)-activating monoclonal antibodies (mAb) to melanoma-associated antigens can be impaired by the levels of expression of C-inhibitory molecules on neoplastic cells.
Sigalotti L, Altomonte M, Fonsatti E, De Nardo C, Colombo MP, Romano G, Visintin A, Nardi G, Maio M, Coral S, Colizzi F   +10 more
core   +1 more source

Expression of Protectin (CD59) in human melanoma and its functional role in cell-mediated and complement-mediated cytotoxicity

, 1995
Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines.
Attadia V, Altomonte M, Gasparollo A, Cattelan A, Maio M, Simonelli C, Gloghini A, Cattarossi I, Brasoveanu LI, Montagner R, Carbone A, Fonsatti E, Coral S   +12 more
core   +1 more source

Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities.

, 2014
International audienceNeutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase (MPO).
Michel Guichardant, Fay, Michèle, Fathi Driss, Boussetta, Tarek, Michel Lagarde, Driss, Fathi, El-Benna, Jamel, Guichardant, Michel, Lagarde, Michel, Tarek Boussetta, Liu, Miao, Michèle Fay, Jamel El‐Benna, Miao Liu, Karama Makni‐Maalej, Makni-Maalej, Karama   +15 more
core   +1 more source

Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway

, 2018
Several studies have demonstrated that protectins, ω-3 fatty acid-derived proresolution mediators, may ameliorate inflammation. Recently, protectin DX (PDX) was also reported to attenuate inflammation and insulin resistance in several cell types ...
Ji Hoon Jeong, Kim, Hyoung-Chun, Hyoung-Chun Kim, Tae Woo Jung, Chung, Yoon Hee, Yoon Hee Chung, Abd El-Aty, A. M., Jeong, Ji Hoon, A. M. Abd El-Aty, Jung, Tae Woo   +9 more
core   +1 more source

Protectin D1 (PD1) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Protectin DX (PDX) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies - (Review)

, 1998
Protectin (CD59) is a glycosyl-phosphatidylinositol-anchored cell membrane glycoprotein, ubiquitously expressed, though to a different extent, on benign and malignant cells.
Sigalotti L, Altomonte M, Fonsatti E, Gasparollo A, Visintin A, Maio M, Coral S, Lamaj E, Brasoveanu LI   +8 more
core  

Roles of Protectin D1 (PD1) and Protectin Conjugate for Tissue Regeneration 1 (PCTR1) During Respiratory Syncytial Virus Infection [PDF]

A27. VIRAL INFECTIONS: IMMUNITY AND BASIC MECHANISMS, 2020
K. Walker, N. Krishnamoorthy, T.R. Brüggeman, P.C. Norris, C.N. Serhan, B.D. Levy   +5 more
openaire   +1 more source

Protectin D1/GPR37 Signaling Enhances Macrophage-Dependent Efferocytosis to Attenuate Experimental Abdominal Aortic Aneurysm Formation. [PDF]

FASEB J
Adithan A, Fassler M, Lu G, Valisno JAC, Su G, Sharma S, Ueland W, Sharma AK, Upchurch GR.   +8 more
europepmc   +1 more source