Results 91 to 100 of about 3,781 (209)

Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX

, 2018
The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10S,17S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and
Jean-Yves Sancéau (6157892), André Marette (1823605), René Maltais (1280025), Donald Poirier (837265)   +3 more
core   +1 more source

Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta

Journal of Lipid Research, 2013
Placental inflammation is associated with several pregnancy disorders. Inflammation is limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated by resolvins and protectins derived from omega-3 polyunsaturated fatty acids (n ...
Megan L. Jones, Peter J. Mark, Jeffrey A. Keelan, Anne Barden, Emilie Mas, Trevor A. Mori, Brendan J. Waddell   +6 more
doaj   +1 more source

Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?

Molecules, 2020
Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska   +7 more
doaj   +1 more source

Eicosapentaenoic and Docosahexaenoic Acid Levels in Mouse Tissues After Intake of Echium and Ahiflower Oils Rich in Stearidonic and α‐Linolenic Acids

Lipids, Volume 61, Issue 3, Page 417-426, May 2026.
Dietary supplementation with stearidonic acid–rich Echium and Ahiflower oils increases EPA levels across multiple mouse tissues, while DHA responses remain tissue‐specific and limited, supporting the strategic use of plant‐based omega‐3 sources for EPA‐focused interventions. ABSTRACT Omega‐3 fatty acids (n‐3 FA), particularly eicosapentaenoic acid (EPA)
Letícia V. Segre, Mariana S. Bisinotto, Inar A. Castro   +2 more
wiley   +1 more source

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation.

, 2009
International audienceOur study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of protectin/neuroprotectin D1 (PD1/NPD1 ...
P. Chen, M. Lagarde, Fenet, Bernard, M. Guichardant, Tomczyk, N., Guichardant, Michel, Michaud, Sabine, E. Véricel, Michaud, S., N. Tomczyk, Lagarde, Michel, Chen, P., Chen, Ping, Véricel, E., Fenet, B., Guichardant, M., Véricel, Evelyne, Lagarde, M., B. Fenet, S. Michaud, Tomczyk, Nick   +20 more
core   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates

, 2020
International audienceBackground and purpose: Specialized pro-resolving mediators (SPMs) are a family of lipids controlling the resolution of inflammation and playing a role in many processes including organ protection and tissue repair.
Farida Djouad, Tamara Sipka, Thierry Durand, Laurence Balas, Luz-Crawford, Patricia, Christian Jorgensen, Mai Nguyen‐Chi, Rafael Contreras‐López, Contreras-López, Rafael, Lutfalla, Georges, Djouad, Farida, Barthelaix, Audrey, Sipka, Tamara, Patricia Luz‐Crawford, Audrey Barthelaix, Durand, Thierry, Nguyen-Chi, Mai, Balas, Laurence, Jorgensen, Christian, Georges Lutfalla   +19 more
core   +1 more source

Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice

, 2021
Diabetic nephropathy (DN) remains the major cause of end-stage renal disease (ESRD). We used high-fat/high-sucrose (HFHS)-fed LDLr-/- /ApoB(100/100) mice with transgenic overexpression of IGFII in pancreatic beta-cells (LRKOB100/IGFII) as a model of ESRD
Trottier, Jocelyn, Perazza, Lais R., Mathieu, Patrick, Barbier, Olivier, Mitchell, Patricia L., Lizotte, Farah, St-Pierre, Philippe, Jensen, Benjamin A. H., Marette, Andre, Geraldes, Pedro M.   +9 more
core   +1 more source

Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling

Molecular Pain
Background . Neuro-inflammatory response promotes the initiation and sustenance of lumbar disc herniation (LDH). Protectin D1 (PD1), as a new type of specialized pro-resolving mediator (SPM), can improve the prognosis of various inflammatory diseases ...
Yu-Chang Zhu, Yi Zhang, Xiao Gao, Ling-Xing Li, Yu-Ru Tang, Yi-Hao Wang   +5 more
doaj   +1 more source

Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

Allergology International, 2015
Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in inflammatory diseases including asthma and allergies ...
Jun Miyata, Makoto Arita
doaj   +1 more source