Results 101 to 110 of about 3,781 (209)

Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Journal of Inflammation Research, 2017
Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of
Fonseca FCS, Orlando RM, Turchetti-Maia RMM, Francischi JN   +3 more
doaj  

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

Frontiers in Pharmacology, 2019
A western type diet and lifestyle play an important role in the development of chronic diseases, yet little insight into the precise cellular and biomolecular mechanisms has emerged. It is known that an unbalanced diet may result in obesity and diabetes.
Trond Vidar Hansen, Anders Vik, Charles N. Serhan   +2 more
doaj   +1 more source

Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression

, 2018
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics.Docosahexaenoic acid (DHA) and its bioactive compounds may have suppressive effects on inflammation, endoplasmic reticulum (ER) stress, and insulin resistance ...
Ji Hoon Jeong, Lee, Sung Hoon, HACIMÜFTÜOĞLU, Ahmet, Eon Sub Park, Eun Jung Kyung, Yong Kyu Shin, Abd El-Aty, A. M., Jeong, Ji Hoon, Park, Eon Sub, Jung, Tae Woo, Sung Hoon Lee, Kyung, Eun Jung, Ahmet Hacımüftüoğlu, Kim, Hyoung-Chun, Hyoung-Chun Kim, Tae Woo Jung, Shin, Yong Kyu, A. M. Abd El-Aty   +17 more
core   +1 more source

Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.

, 1990
Human cells are relatively resistant to lysis by the homologous complement system. Here we describe the mechanism of action of a recently discovered and widely distributed 18,000-20,000 molecular weight (MW) membrane glycoprotein (CD59), which appears to
Meri, S, Davies, A, Lachmann, PJ, Morgan, BP, Olavesen, MG, Waldmann, Herman, Daniels, RH   +6 more
core  

Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice

Scientific Reports, 2017
Protectin DX (PDX), a double lipoxygenase derivative of docosahexaenoic acid, has been reported to attenuate inflammation and insulin resistance. In the current study, we explored the effects of PDX on hyperlipidemia-induced insulin resistance and ...
Tae Woo Jung, Hyoung-Chun Kim, A. M. Abd El-Aty, Ji Hoon Jeong   +3 more
doaj   +1 more source

Protectin DX suppresses hepatic gluconeogenesis through AMPK-HO-1-mediated inhibition of ER stress

, 2017
Several studies have shown that protectins, which are ca-3 fatty acid-derived proresolution mediators, may improve insulin resistance. Recently, protectin DX (PDX) was documented to attenuate insulin resistance by stimulating IL-6 expression in skeletal ...
Ji Hoon Jeong, Tae Woo Jung, A.M. Abd El-Aty, Abd El-Aty, A. M., Jeong, Ji Hoon, Jung, Tae Woo, Kim, Hyung-Chun, Hyung-Chun Kim   +7 more
core   +1 more source

Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators

The Scientific World Journal, 2010
The enzymatic oxygenation of polyunsaturated fatty acids by lipoxygenases and cyclo-oxygenases is a resourceful mode of formation of specific autacoids that regulate the extent and pace of the inflammatory response. Arachidonate-derived eicosanoids, such
Gerard L. Bannenberg
doaj   +1 more source

Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression

Retrovirology, 2010
Background Previously, we showed that glioma pathogenesis related protein (GliPR) is induced in CEM T cells upon HIV-1 infection in vitro. To examine whether GliPR plays a role as HIV dependency factor (HDF), we tested the effect of GliPR suppression by ...
Ottmann Oliver G, Hoelzer Dieter, Dietrich Ursula, Müller-Kuller Thea, Capalbo Gianni, Scheuring Urban J   +5 more
doaj   +1 more source

protectin

Citation: 'protectin' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13614 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Synthesis and Identification of AceDoxyPC, a Protectin-Containing Structured Phospholipid, Using Liquid Chromatography/Mass Spectrometry

, 2017
International audienceFatty acids have many health benefits in a great variety of diseases ranging from cardiovascular to cerebral diseases. For instance, docosahexaenoic acid (DHA), which is highly enriched in brain phospholipids, plays a major role in ...
Michel Guichardant, Bernoud-Hubac, Nathalie, Lagarde, Michel, Fourmaux, B., Madeleine Picq, Baptiste Fourmaux, Nathalie Bernoud-Hubac, Michel Lagarde, Picq, Madeleine, Guichardant, Michel, Lo Van, Amanda, Amanda Lo Van   +11 more
core   +1 more source