Results 101 to 110 of about 3,813 (208)

The Docosatriene Protectin D1 Is Produced by T H 2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering [PDF]

, 2019
Docosahexaenoic acid, a major omega-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated.
Li, Pin-Lan, Wang, Wei, Ariel, Amiram, Gotlinger, Katherine H., Fredman, Gabrielle, Tang, Wang-Xian, Serhan, Charles N., Hong, Song   +7 more
core   +1 more source

Omega‐3 Long‐Chain Polyunsaturated Fatty Acid Metabolite 16‐Hydroxydocosahexaenoic Acid Strengthens Non‐Small Cell Lung Cancer Radiosensitivity Through Peroxisome Proliferator‐Activated Receptor γ

Food Frontiers, Volume 7, Issue 4, July 2026.
This study revealed a novel mechanism by which ω‐3 LCPUFA metabolism regulated NSCLC cell radiosensitivity. Specific ω‐3 LCPUFA metabolite 16‐HDHA plasma levels were elevated in the radiosensitive NSCLC patients and enhanced the cytotoxic effects of radiation on NSCLC cells.
Mengqin Wang, Jiang Luo, Mini Zhang, Shuling Li, Jiawen Tang, Qingwei Wang, Yuzhu Wu, Ziyu Jiang, Conghua Xie, Yan Gong   +9 more
wiley   +1 more source

Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta

Journal of Lipid Research, 2013
Placental inflammation is associated with several pregnancy disorders. Inflammation is limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated by resolvins and protectins derived from omega-3 polyunsaturated fatty acids (n ...
Megan L. Jones, Peter J. Mark, Jeffrey A. Keelan, Anne Barden, Emilie Mas, Trevor A. Mori, Brendan J. Waddell   +6 more
doaj   +1 more source

Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?

Molecules, 2020
Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska   +7 more
doaj   +1 more source

Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling

Molecular Pain
Background . Neuro-inflammatory response promotes the initiation and sustenance of lumbar disc herniation (LDH). Protectin D1 (PD1), as a new type of specialized pro-resolving mediator (SPM), can improve the prognosis of various inflammatory diseases ...
Yu-Chang Zhu, Yi Zhang, Xiao Gao, Ling-Xing Li, Yu-Ru Tang, Yi-Hao Wang   +5 more
doaj   +1 more source

Overexpression of protectin (CD59) down-modulates the susceptibility of human melanoma cells to homologous complement [PDF]

, 2000
The clinical efficacy of therapeutic complement (C)-activating monoclonal antibodies (mAb) to melanoma-associated antigens can be impaired by the levels of expression of C-inhibitory molecules on neoplastic cells.
Sigalotti L, Altomonte M, Fonsatti E, De Nardo C, Colombo MP, Romano G, Visintin A, Nardi G, Maio M, Coral S, Colizzi F   +10 more
core   +1 more source

Expression of Protectin (CD59) in human melanoma and its functional role in cell-mediated and complement-mediated cytotoxicity [PDF]

, 1995
Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines.
Attadia V, Altomonte M, Gasparollo A, Cattelan A, Maio M, Simonelli C, Gloghini A, Cattarossi I, Brasoveanu LI, Montagner R, Carbone A, Fonsatti E, Coral S   +12 more
core   +1 more source

Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

Allergology International, 2015
Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in inflammatory diseases including asthma and allergies ...
Jun Miyata, Makoto Arita
doaj   +1 more source

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

Frontiers in Pharmacology, 2019
A western type diet and lifestyle play an important role in the development of chronic diseases, yet little insight into the precise cellular and biomolecular mechanisms has emerged. It is known that an unbalanced diet may result in obesity and diabetes.
Trond Vidar Hansen, Anders Vik, Charles N. Serhan   +2 more
doaj   +1 more source

Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Journal of Inflammation Research, 2017
Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of
Fonseca FCS, Orlando RM, Turchetti-Maia RMM, Francischi JN   +3 more
doaj