Results 81 to 90 of about 3,781 (209)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Synthesis and Anti-inflammatory and Pro-resolving Activities of 22- OH-PD1, a Monohydroxylated Metabolite of Protectin D1

, 2015
: Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators.
Marius Aursnes, Anders Vik, Dalli, Jesmond, Romain A. Colas (1340859), Jesmond Dalli (241689), Hansen, Trond V., Aursnes, Marius, Jørn E. Tungen, Sesquile Ramon, Jesmond Dalli, Romain A. Colas, Charles N. Serhan (82808), Vik, Anders, Anders Vik (1316910), Trond V. Hansen (1316919), Jørn E. Tungen (1316907), Sesquile Ramon (1340856), Serhan, Charles, Marius Aursnes (1316904), Tungen, Jørn E., Ramon, Sesquile, Charles N. Serhan, Trond V. Hansen, Colas, Romain A.   +23 more
core   +1 more source

Enzymatic Formation of Protectin Dx and Its Production by Whole-Cell Reaction Using Recombinant Lipoxygenases

, 2022
In the human body, docosahexaenoic acid (DHA) contained in fish oil is converted to trace amounts of specialized pro-resolving mediators (SPMs) as the principal bioactive metabolites for their pharmacological effects.
Kyung-Chul Shin, Yoon-Joo Ko, Min-Ju Seo, Su-Eun Kim, Tae-Eui Lee, Deok-Kun Oh   +5 more
core   +1 more source

Resolvin E1 and protectin D1 activate inflammation-resolution programmes [PDF]

Nature, 2007
Resolution of acute inflammation is an active process essential for appropriate host responses, tissue protection and the return to homeostasis. During resolution, specific omega-3 polyunsaturated fatty-acid-derived mediators are generated within resolving exudates, including resolvin E1 (RvE1) and protectin D1 (PD1).
Jan M, Schwab, Nan, Chiang, Makoto, Arita, Charles N, Serhan   +3 more
openaire   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis

, 1995
Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis. Protectin (CD59) is a low molecular weight glycophosphoinositol-anchored inhibitor of the membrane attack complex of complement (MAC) that is present,
Lehto, Timo, Meri, Seppo, Honkanen, Eero, Teppo, Anna-Maija   +3 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Toll‐like receptor 7 stimulates production of specialized pro‐resolving lipid mediators and promotes resolution of airway inflammation

EMBO Molecular Medicine, 2013
Although specialized pro‐resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive.
Ourania Koltsida, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini‐Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N. Serhan, Evangelos Andreakos   +8 more
doaj   +1 more source

The future of periodontology: Emerging technologies and conceptual shifts

Journal of Periodontology, Volume 97, Issue 5, Page 875-882, May 2026.
Abstract Periodontology is entering a transformative era driven by advances in diagnostics, therapeutics, and digital integration. Emerging technologies and conceptual shifts are currently reshaping the specialty, with a focus on predictive, preventive, and personalized care.
Michael S. Reddy
wiley   +1 more source

Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues.

, 1991
Protectin (CD59) is a recently discovered 18-20 kDa glycoprotein that effectively inhibits lysis by the membrane attack complex of the homologous complement system.
Meri, S, Lachmann, PJ, Waldmann, H, Waldmann, Herman   +3 more
core