Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues. [PDF]
, 1991 Protectin (CD59) is a recently discovered 18-20 kDa glycoprotein that effectively inhibits lysis by the membrane attack complex of the homologous complement system.
Meri, S +3 more
core
Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX [PDF]
, 2018 The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10S,17S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and
Jean-Yves Sancéau (6157892) +3 more
core +1 more source
Respiratory Research, 2021 Background Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel macrophage-derived lipid mediator exhibiting potential ...
Xin-Yang Wang +9 more
doaj +1 more source
Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. [PDF]
, 2009 International audienceOur study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of protectin/neuroprotectin D1 (PD1/NPD1 ...
P. Chen +20 more
core +1 more source
Protectin DX Relieve Hyperoxia‐induced Lung Injury by Protecting Pulmonary Endothelial Glycocalyx
Journal of Inflammation Research, 2023 Zhongjie Liang,1,2 Huilin Yue,1 Congcong Xu,1 Qian Wang,3 Shengwei Jin2,3 1Department of Neonatology, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2Department of ...
Liang Z, Yue H, Xu C, Wang Q, Jin S
doaj
iMetaOmics, EarlyView.Advances in sequencing and mass spectrometry have propelled life sciences into the multi‐omics era. Metabolomics and microbiomics are widely applied across various research fields, yet massive data analysis faces challenges like limited tool functionality and high technical barriers.
Jianhua Zhao +16 more
wiley +1 more source
Frontiers in ImmunologySepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun +22 more
doaj +1 more source
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis [PDF]
, 2018 Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of the disease (epileptogenesis). There are no treatments for preventing seizures or improving disease prognosis, including neurological comorbidities.
Marchini, S +33 more
core +2 more sources
Pro‐resolving mediator protectin D1 promotes epimorphic regeneration by controlling immune cell function in vertebrates [PDF]
, 2020 International audienceBackground and purpose: Specialized pro-resolving mediators (SPMs) are a family of lipids controlling the resolution of inflammation and playing a role in many processes including organ protection and tissue repair.
Farida Djouad +19 more
core +1 more source
Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice [PDF]
, 2021 Diabetic nephropathy (DN) remains the major cause of end-stage renal disease (ESRD). We used high-fat/high-sucrose (HFHS)-fed LDLr-/- /ApoB(100/100) mice with transgenic overexpression of IGFII in pancreatic beta-cells (LRKOB100/IGFII) as a model of ESRD
Trottier, Jocelyn +9 more
core +1 more source