Results 51 to 60 of about 3,813 (208)

2204 Characterizing specialized pro-resolving lipid mediators and synthesis pathways in veterans with peripheral artery disease

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: Specialized pro-resolving lipid mediators (SPM) actively counter proinflammatory cascades. A deficit of SPMs is one possible mechanism through which inflammation leads to the development of atherosclerotic disease.
Joel Ramirez, Greg J. Zahner, Sukaynah A. Khetani, Kimberly A. Spaulding, Nancy K. Hills, S. Marlene Grenon   +5 more
doaj   +1 more source

Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection [PDF]

, 2019
The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue injury.
Deraison, Celine, Alric, Laurent, Dalli, Jesmond, Gobbetti, Thomas, Hansen, Trond, Bonnet, Delphine, Aursnes, Marius, Vergnolle, Nathalie, Serhan, Charles, Canova, Donata Federici, Colas, Romain, Perretti, Mauro   +11 more
core   +1 more source

The potential of exogenous specialized pro-resolving mediators in protecting against sepsis-associated lung injury: a review

Frontiers in Pharmacology
Sepsis-associated lung injury (SALI) is a critical condition with high mortality. Current therapies are limited, necessitating novel approaches. This review highlights the potential of exogenous Specialized Pro-resolving Mediators (SPMs), including ...
Jiwei Shen, Jiwei Shen, Jiwei Shen, Huiqin Shen, Huiqin Shen, Huiqin Shen, Shujun Sun, Shujun Sun, Shujun Sun, Shiwen Fan, Shiwen Fan, Shiwen Fan, Tianhao Zhang, Tianhao Zhang, Tianhao Zhang, Guobin Song, Guobin Song, Guobin Song, Ning An, Ning An, Ning An, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +26 more
doaj   +1 more source

Synthesis and Anti-inflammatory and Pro-resolving Activities of 22- OH-PD1, a Monohydroxylated Metabolite of Protectin D1 [PDF]

, 2015
: Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators.
Marius Aursnes, Anders Vik, Dalli, Jesmond, Romain A. Colas (1340859), Jesmond Dalli (241689), Hansen, Trond V., Aursnes, Marius, Jørn E. Tungen, Sesquile Ramon, Jesmond Dalli, Romain A. Colas, Charles N. Serhan (82808), Vik, Anders, Anders Vik (1316910), Trond V. Hansen (1316919), Jørn E. Tungen (1316907), Sesquile Ramon (1340856), Serhan, Charles, Marius Aursnes (1316904), Tungen, Jørn E., Ramon, Sesquile, Charles N. Serhan, Trond V. Hansen, Colas, Romain A.   +23 more
core   +1 more source

Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Frontiers in Immunology, 2012
Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to ...
Yosuke eIsobe, Taiga eKato, Makoto eArita, Makoto eArita   +3 more
doaj   +1 more source

Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues

Future Medicinal Chemistry, 2022
Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Kevin Daly, Killian O'Sullivan, Timothy P O'Sullivan   +2 more
openaire   +3 more sources

Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis [PDF]

, 1995
Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis. Protectin (CD59) is a low molecular weight glycophosphoinositol-anchored inhibitor of the membrane attack complex of complement (MAC) that is present,
Lehto, Timo, Meri, Seppo, Honkanen, Eero, Teppo, Anna-Maija   +3 more
core   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Optimizing complement-activating antibody-based cancer immunotherapy: a feasible strategy?

Journal of Translational Medicine, 2004
Passive immunotherapy with monoclonal antibodies (mAb) targeted to specific tumor-associated antigens is amongst the most rapidly expanding approaches to biological therapy of cancer.
Maio Michele, Di Giacomo Anna, Fonsatti Ester   +2 more
doaj   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source