Results 51 to 60 of about 3,781 (209)

Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induced pulmonary endothelial glycocalyx loss via ALX/SIRT1/NF-kappa B axis

Respiratory Research, 2021
Background Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates in tissue regeneration 1 (PCTR1) is a novel macrophage-derived lipid mediator exhibiting potential ...
Xin-Yang Wang, Xin-Yu Li, Cheng-Hua Wu, Yu Hao, Pan-Han Fu, Hong-Xia Mei, Fang Chen, Yu-Qiang Gong, Sheng-Wei Jin, Hui Li   +9 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The complement-inhibiting protein, Protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells

, 1991
SUMMARY Protectin (CDS9 antigen) is a 20-kD phosphatidyl-inositol-linked membrane protein that inhibits formation of the membrane attack complex (MAC) of complement on homologous cells.
Griffiths, David Francis Rees, A DAVIES, D GRIFFITHS, Rooney, I. A., Meri, S., J D WILLIAMS, Williams, John David, Lachmann, P. J., P J LACHMANN, Davies, A., S MERI, B P MORGAN, M DAVIES, I A ROONEY, Davies, M., Morgan, B. P.   +15 more
core   +1 more source

Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review

Frontiers in Immunology
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death.
Shujun Sun, Shujun Sun, Shujun Sun, Shujun Sun, Dong Yang, Dong Yang, Dong Yang, Jing Lv, Jing Lv, Jing Lv, Haifa Xia, Haifa Xia, Haifa Xia, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Zhangyan Mao, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao   +22 more
doaj   +1 more source

Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase[S]

Journal of Lipid Research, 2013
Resolvins and protectins are important anti-inflammatory and pro-resolution compounds derived from the enzymatic oxidation of omega-3 fatty acids all-cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and all-cis-4,7,10,13,16,19-docosahexaenoic acid (DHA).
Eleanor P. Dobson, Colin J. Barrow, Jaroslav A. Kralovec, Jacqui L. Adcock   +3 more
doaj   +1 more source

Protectin DX restores Treg/Th17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a

Cell Death and Disease, 2021
Regulatory T-cell (Treg)/T-helper 17 (Th17) cell balance plays an important role in the progression of rheumatoid arthritis (RA). Our study explored the protective effect of protectin DX (PDX), which restored Treg/Th17 cell balance in RA, and the role of
Shengwei Jin, Siyuan Sun, Hanzhi Ling, Jinglan Ma, Xu Zhang, Zhen Xie, Ning Zhan, Wenjie Zheng, Man Li, Yang Qin, Heping Zhao, Yan Chen, Xinyu Yang, Jianguang Wang   +13 more
doaj   +1 more source

Extracellular domain of type I receptor for transforming growth factor-β: molecular modelling using protectin (CD59) as a template

, 1995
We have observed that the extracellular domain of TβRI and protectin (CD59), an inhibitor of the membrane attack complex of complement, share structural features, a distinct spacing of ten cysteines and a C-terminal ‘Cys-box’.
Tissari, Jorma, Olle Teleman, Jokiranta, T.Sakari, Teleman, Olle, T.Sakari Jokiranta, Meri, Seppo, Seppo Meri, Jorma Tissari, Jokiranta, T. Sakari   +8 more
core   +1 more source

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis [PDF]

, 2018
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of the disease (epileptogenesis). There are no treatments for preventing seizures or improving disease prognosis, including neurological comorbidities.
Marchini, S, Pistorius, K, Dalli, Jesmond, Hansen, TV, Craparotta, Ilaria, Leclercq, K, Frigerio, Federica, Perretti, M, Perretti, Mauro, Craparotta, I, Pasqualini, G, Marchini, Sergio, Kaminski, RM, Pasqualini, Giulia, Dalli, J, Frigerio, F, Foerch, P, Aronica, E, van Vliet, Erwin A., Kaminski, Rafal M., Foerch, Patrick, Hansen, Trond V., Aronica, Eleonora, Vandenplas, C, Colas, RA, Porcu, L, Porcu, Luca, Vandenplas, Catherine, Leclercq, Karin, Colas, Romain A., van Vliet, EA, Vezzani, A, Vezzani, Annamaria, Pistorius, Kimberly   +33 more
core   +1 more source

Clostridium butyricum Modulates the Microbiome to Protect Intestinal Barrier Function in Mice with Antibiotic-Induced Dysbiosis

iScience, 2020
Summary: Clostridium butyricum MIYAIRI 588 (CBM 588) is a probiotic bacterium that has previously been used to prevent antibiotic-associated diarrhea. However, the underlying mechanism by which CBM 588 protects the gut epithelial barrier remains unclear.
Mao Hagihara, Yasutoshi Kuroki, Tadashi Ariyoshi, Seiya Higashi, Kazuo Fukuda, Rieko Yamashita, Asami Matsumoto, Takeshi Mori, Kaoru Mimura, Naoko Yamaguchi, Shoshiro Okada, Tsunemasa Nonogaki, Tadashi Ogawa, Kenta Iwasaki, Susumu Tomono, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Yuka Yamagishi, Motomichi Takahashi, Hiroshige Mikamo   +20 more
doaj   +1 more source

Emerging locally delivered antimicrobial and immunomodulatory approaches for the prevention/treatment of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje, Ettore Amerio, Irene Mallor, Conrado Aparicio   +3 more
wiley   +1 more source