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Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues
Future Medicinal Chemistry, 2022 Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Timothy O'Sullivan
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Resolvins and protectins in the termination program of acute inflammation
Trends in Immunology, 2007The physiological resolution of a well-orchestrated inflammatory response is essential to maintain homeostasis. Therefore, gaining a comprehensive understanding in molecular terms of the events that direct the termination of acute inflammation is imperative.
Amiram Ariel, Charles N Serhan
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Novel Chemical Mediators in the Resolution of Inflammation: Resolvins and Protectins
Anesthesiology Clinics, 2006Resolvins and protectins are new families consisting of distinct chemical series of lipid-derived mediators, each with unique structures and apparent complementary anti-inflammatory actions. Both families of compounds, Rv and protectins, are also generated when aspirin is given in mammalian systems in their respective epimeric forms.
Charles N Serhan
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Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis
Journal of Neuroimmunology, 2004Immunohistochemical stainings for protectin (CD59) and for the macrophage/monocyte antigen were performed in muscle specimens of polymyositis (PM) and dermatomyositis (DM) patients. In control muscles, a granular immunostaining of CD59 at the surface of 10-15% from among muscle fibers and an intense reaction in endothelia of blood vessels were noted ...
Hanna, Gendek-Kubiak, Ewa G, Gendek
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Biochimie, 2014
There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non-cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects.
Balas, Laurence +3 more
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There is currently a growing interest in docosahexaenoic acid (DHA) oxygenated metabolites. Among them, protectin D1 (PD1), an endogenous dihydroxylated and non-cyclic docosatriene made through lipoxygenation and hydrolysis of an epoxide intermediate, shows appealing biological effects.
Balas, Laurence +3 more
openaire +4 more sources
Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation
International Immunopharmacology, 2021Specialized proresolving mediators are enzymatically oxygenated natural molecules derived from polyunsaturated fatty acids and are considered novel. These novel mediators include lipoxins from arachidonic acid, resolvins and protectins from omega-3 essential fatty acids, and new maresins.
Kyung-Duck, Park +8 more
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Lipoxins, resolvins and protectins: new leads for the treatment of asthma
Expert Opinion on Drug Discovery, 2008The pathobiology of asthma is characterized by the production of pro-inflammatory eicosanoids that play important roles in regulating airway responses. Recognition of the biosynthetic pathways and sites of action for 5-lipoxygenase-derived leukotrienes has led to the successful development of two different classes of asthma therapeutics.In this review,
Oliver, Haworth, Bruce D, Levy
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Protectins in Argentine Mollusks: Immunological and Immunochemical Aspects
1975Protectins and agglutinins in several organs, fluids and spawn from Argentine terrestrial and fresh-water gastropod species were examined. Differences or analogies with vertebrate immunoglobulin serological behaviour are summarized. Individual or group variability and the evolutionary meaning of the reproductive system-linked and the Ca++ ion-linked ...
M, Palatnik +3 more
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The serological specificity of snail agglutinins (protectins)4
Animal Blood Groups and Biochemical Genetics, 1972G. Uhlenbruck +3 more
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