Results 181 to 190 of about 7,413 (211)

Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations

Histochemistry and Cell Biology, 2018
The goal of the present studies is to investigate that the impact of p-cresylsulfate (PCS) on the endothelial barrier integrity via in situ exposure and systemic exposure. Vascular permeability changes induced by local injection of PCS were evaluated by the techniques of both Evans blue (EB) and India ink tracer.
Wei-Hua Tang, Chao-Ping Wang, Teng-Hung Yu, Pei-Yang Tai, Shih-Shin Liang, Wei-Chin Hung, Cheng-Ching Wu, Sung-Hao Huang, Yau-Jiunn Lee, Shih-Chieh Chen   +9 more
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Targeting protein-bound uremic toxins in chronic kidney disease

Expert Opinion on Therapeutic Targets, 2013
Protein-bound uremic toxins such as indoxyl sulfate cannot be removed efficiently by hemodialysis. These protein-bound uremic toxins have emerged as important risk factors for the progression of chronic kidney disease (CKD) as well as cardiovascular disease (CVD).Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular ...
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Improved dialysis removal of protein-bound uremic toxins by salvianolic acids

Phytomedicine, 2019
Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are two key protein-bound uremic toxins that accumulate in patients with end-stage renal disease. IS and pCS cannot be efficiently removed by conventional hemodialysis because they are highly bound to proteins.
Jianping, Li, Yingyi, Wang, Xuejun, Xu, Wenjuan, Cao, Zhiqiang, Shen, Nan, Wang, Jing, Leng, Ning, Zou, Erxin, Shang, Zhenhua, Zhu, Jianming, Guo, Jinao, Duan   +11 more
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Removal of Protein-Bound Uremic Toxins by Liposome-Supported Peritoneal Dialysis

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2019
Background Protein-bound uremic toxins (PBUTs) are poorly cleared by peritoneal dialysis (PD). This study aimed to enhance PBUT removal in PD by adding a binder to the peritoneal dialysate and to evaluate the feasibility and efficacy of liposome-supported PD (LSPD) to increase the removal of PBUTs compared with albumin PD.
Yuanyuan, Shi, Huajun, Tian, Yifeng, Wang, Yue, Shen, Qiuyu, Zhu, Feng, Ding   +5 more
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Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome

American Journal of Physiology-Renal Physiology, 2016
Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart.
Suree, Lekawanvijit, Andrew R, Kompa, Henry, Krum   +2 more
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Vascular Incompetence in Dialysis Patients—Protein‐Bound Uremic Toxins and Endothelial Dysfunction

Seminars in Dialysis, 2011
AbstractPatients with chronic kidney disease (CKD) have a much higher risk of cardiovascular diseases than the general population. Endothelial dysfunction, which participates in accelerated atherosclerosis, is a hallmark of CKD. Patients with CKD display impaired endothelium‐dependent vasodilatation, elevated soluble biomarkers of endothelial ...
Jourde-Chiche, Noemie, Dou, Laetitia, Cerini, Claire, Dignat-George, Francoise, Brunet, Philippe   +4 more
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Increasing the removal of protein‐bound uremic toxins by liposome‐supported hemodialysis

Artificial Organs, 2018
AbstractProtein‐bound uremic toxins (PBUTs) accumulate at high plasma levels and cause various deleterious effects in end‐stage renal disease patients because their removal by conventional hemodialysis is severely limited by their low free‐fraction levels in plasma.
Yuanyuan Shi, Yifeng Wang, Shuai Ma, Tingyan Liu, Huajun Tian, Qiuyu Zhu, Wenji Wang, Yulin Li, Feng Ding   +8 more
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Update on the Pharmacokinetics and Redox Properties of Protein-Bound Uremic Toxins

Journal of Pharmaceutical Sciences, 2011
Protein-bound uremic toxins, such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, p-cresyl sulfate, hippuric acid, and indoleacetic acid, have been the subjects of extensive investigations. In this review, we summarized the recent works providing the new insight on the pharmacokinetics and redox properties of these uremic toxins.
Hiroshi, Watanabe, Yohei, Miyamoto, Masaki, Otagiri, Toru, Maruyama   +3 more
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[Uremic toxins: the case of protein-bound compounds].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2010
Uremic retention solutes, if biologically or biochemically active, are called ''uremic toxins''. The retention of these solutes has a negative impact on many functions of the organism, particularly the cardiovascular system. The classification which is applied today is based on the kinetic behavior of the uremic retention solutes during dialysis: 1 ...
Carlo, Basile, Pasquale, Libutti, Annalisa, Teutonico, Carlo, Lomonte   +3 more
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New therapeutic perspectives on protein-bound uremic toxins in chronic kidney disease

Expert Opinion on Therapeutic Targets, 2013
The uremic syndrome is a complex mosaic of clinical alterations that may be attributable to one or more of these different solutes. Uremic symptoms in patients with chronic kidney disease are primarily a consequence of inadequate removal and subsequent accumulation of organic products normally metabolized or excreted by the kidney.
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