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Kinetics of protein-bound uremic toxins in chronic kidney disease

, 2018
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Protein-Bound Uremic Toxins and Immunity

2021
Protein-bound uremic toxins (PBUTs) are bioactive microbiota metabolites originated exclusively from protein fermentation of the bacterial community resident within the gut microbiota, whose composition and function is profoundly different in the chronic kidney disease (CKD) population. PBUTs accumulate in the later stages of CKD because they cannot be
Rocchetti M. T., Cosola C., Ranieri E., Gesualdo L.   +3 more
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The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells [PDF]

Biochimie, 2021
International audiencePatients with chronic kidney disease (CKD) often exhibit increased level of oxidative stress that contribute to the deterioration of renal function and uremic complications.
Emilie Bres, Daleprane Jb, Koppe Laetitia   +2 more
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Cardiorenal Syndrome: Role of Protein-Bound Uremic Toxins

Journal of Renal Nutrition, 2015
Renal impairment is a strong independent risk factor associated with poor prognosis in cardiovascular disease patients. Renal dysfunction is likely contributed by progressive renal structural damage. Accurate detection of kidney injury in a timely manner as well as increased knowledge of the pathophysiology and mechanisms underlying this injury is of ...
Suree, Lekawanvijit, Henry, Krum
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Update on the Pharmacokinetics and Redox Properties of Protein-Bound Uremic Toxins

Journal of Pharmaceutical Sciences, 2011
Protein-bound uremic toxins, such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, p-cresyl sulfate, hippuric acid, and indoleacetic acid, have been the subjects of extensive investigations. In this review, we summarized the recent works providing the new insight on the pharmacokinetics and redox properties of these uremic toxins.
Hiroshi, Watanabe, Yohei, Miyamoto, Masaki, Otagiri, Toru, Maruyama   +3 more
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PROGRESS IN UREMIC TOXIN RESEARCH: Protein‐Bound Toxins—Update 2009

Seminars in Dialysis, 2009
AbstractProtein‐bound uremic retention solutes constitute a group whose common characteristic is their difficult removal by dialysis. In 2003, the EUTox group described 25 protein‐bound solutes. They comprised six advanced glycation end products (AGE), four phenols (including p‐cresol), six indoles (including indoxylsulfate), two hippurates, three ...
Noémie Jourde‐Chiche, Laetitia Dou, Claire Cerini, Françoise Dignat‐George, Raymond Vanholder, Philippe Brunet   +5 more
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Improved dialysis removal of protein-bound uremic toxins by salvianolic acids

Phytomedicine, 2019
Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are two key protein-bound uremic toxins that accumulate in patients with end-stage renal disease. IS and pCS cannot be efficiently removed by conventional hemodialysis because they are highly bound to proteins.
Jianping, Li, Yingyi, Wang, Xuejun, Xu, Wenjuan, Cao, Zhiqiang, Shen, Nan, Wang, Jing, Leng, Ning, Zou, Erxin, Shang, Zhenhua, Zhu, Jianming, Guo, Jinao, Duan   +11 more
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Increasing the removal of protein‐bound uremic toxins by liposome‐supported hemodialysis

Artificial Organs, 2018
AbstractProtein‐bound uremic toxins (PBUTs) accumulate at high plasma levels and cause various deleterious effects in end‐stage renal disease patients because their removal by conventional hemodialysis is severely limited by their low free‐fraction levels in plasma.
Yuanyuan Shi, Yifeng Wang, Shuai Ma, Tingyan Liu, Huajun Tian, Qiuyu Zhu, Wenji Wang, Yulin Li, Feng Ding   +8 more
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Targeting protein-bound uremic toxins in chronic kidney disease

Expert Opinion on Therapeutic Targets, 2013
Protein-bound uremic toxins such as indoxyl sulfate cannot be removed efficiently by hemodialysis. These protein-bound uremic toxins have emerged as important risk factors for the progression of chronic kidney disease (CKD) as well as cardiovascular disease (CVD).Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular ...
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Removal of Protein-Bound Uremic Toxins by Liposome-Supported Peritoneal Dialysis

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2019
Background Protein-bound uremic toxins (PBUTs) are poorly cleared by peritoneal dialysis (PD). This study aimed to enhance PBUT removal in PD by adding a binder to the peritoneal dialysate and to evaluate the feasibility and efficacy of liposome-supported PD (LSPD) to increase the removal of PBUTs compared with ...
Yuanyuan, Shi, Huajun, Tian, Yifeng, Wang, Yue, Shen, Qiuyu, Zhu, Feng, Ding   +5 more
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