Results 191 to 200 of about 7,413 (211)

Kinetics of the protein-bound, lipophilic, uremic toxin p-cresol in healthy rats

Life Sciences, 2001
P-Cresol, a partially lipophilic and protein-bound compound is related to several biochemical alterations in uremia. Because p-cresol kinetics have never been studied, we investigated its kinetic behavior in rats. Results were compared with those obtained with creatinine, a water soluble, non-protein-bound uremic retention solute, which is currently ...
Lesaffer, Gerrit, De Smet, R., Dheuvaert, T, Belpaire, F.m., Lameire, N, Vanholder, Raymond   +5 more
openaire   +3 more sources

Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis

Carbohydrate Polymers, 2020
Accumulation of protein-bound uremic toxins (PBUTs) has a high incidence in the blood of hemodialysis-treated patients with chronic kidney disease. Development of adsorbent for the high-efficient, selective, and removal of various PBUTs is still challenging because of their strong interactions to the corresponding binding proteins and the complex blood
Jingyu, Li, Lulu, Han, Jian, Xie, Shuxin, Liu, Lingyun, Jia   +4 more
openaire   +2 more sources

Exploring binding characteristics and the related competition of different protein-bound uremic toxins

Biochimie, 2017
Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of ...
Olivier Deltombe, Henriette de Loor, Griet Glorieux, Annemieke Dhondt, Wim Van Biesen, Björn Meijers, Sunny Eloot   +6 more
openaire   +2 more sources

New Optical Method for Estimation of Protein Bound Uremic Toxins Elimination

2013
The aim of this study was to investigate the possibility to determine the amount of removed Indoxyl Sulphate (IS) during dialysis session. An optical method using fluorescence spectra was used.
J. Holmar, J. Arund, F. Uhlin, R. Tanner, I. Fridolin   +4 more
openaire   +1 more source

Animal Models for Studying Protein-Bound Uremic Toxin Removal

Journal of the American Society of Nephrology, 2023
Sabbir Ahmed, Joost C. de Vries, Jingyi Lu, Milan H. Verrijn Stuart, Silvia M. Mihaila, Robin W. Vernooij, Rosalinde Masereeuw, Karin G. Gerritsen   +7 more
openaire   +1 more source

Clearance of Protein-Bound Uremic Toxins Using Anion Nanotraps with Record High Uptake

ACS Applied Materials & Interfaces
Traditional hemodialysis often fails to remove protein-bound uremic toxins (PBUTs) like p-cresyl sulfate (pCS) and indoxyl sulfate (IS) due to their strong binding to human serum albumin, which is linked to adverse cardiovascular outcomes. Herein, a class of cationic polymeric networks, denoted as CPN-X6-CPN-X9, are reported for the efficient removal ...
Meiyu Zhang, Yujie Miao, Ping Zhang, Chengliang Xiao   +3 more
openaire   +2 more sources

Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease

Translational Research, 2021
Monica Faria, Maria Norberta de Pinho
exaly  

Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence

Toxins, 2022
Jia-Huang Chen, Chih-Kang Chiang
exaly  

Clearance of Protein-Bound Uremic Toxins on the Tablo Hemodialysis System

Journal of the American Society of Nephrology, 2021
Logan Rivas, Dean Hu, Michael A. Aragon
openaire   +1 more source

The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells

Biochimie, 2021
Laetitia Koppe, Team1 Carmen, Bérengère Benoit   +2 more
exaly