Results 1 to 10 of about 32,649 (220)

Characterization of trans-3-Methylglutaconyl CoA-Dependent Protein Acylation [PDF]

Metabolites, 2023
3-methylglutaconyl (3MGC) CoA hydratase (AUH) is the leucine catabolism pathway enzyme that catalyzes the hydration of trans-3MGC CoA to 3-hydroxy, 3-methylglutaryl (HMG) CoA.
Elizabeth A. Jennings, Edward Cao, Irina Romenskaia, Robert O. Ryan   +3 more
doaj   +2 more sources

The function and mechanism of protein acylation in the regulation of viral infection [PDF]

Virulence
Protein acylation modification is one of the most important protein post-translational modifications, which regulates the function of the protein by adding acyl groups to the residues of the protein.
Lei Song, Ziang Wei, Pan Shang, Shijie Hu, Lei Chen, Lili Niu, Yan Wang, Mailin Gan, Linyuan Shen, Li Zhu, Ye Zhao   +10 more
doaj   +2 more sources

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies [PDF]

Cell Communication and Signaling
Protein acylation, a critical subset of post-translational modifications (PTMs), serves as a dynamic regulatory mechanism linking cellular metabolism, epigenetic regulation, and inflammatory responses.
Jiayi Ding, Huiyi Wang, Zhengkun Yang, Xiaoxuan Wang, Zhengguo Cao   +4 more
doaj   +2 more sources

Protein acylation: mechanisms, biological functions and therapeutic targets [PDF]

Signal Transduction and Targeted Therapy, 2022
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
doaj   +2 more sources

The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing. [PDF]

PLoS ONE, 2016
In recent years, various large-scale proteomic studies have demonstrated that mitochondrial proteins are highly acylated, most commonly by addition of acetyl and succinyl groups. These acyl modifications may be enzyme catalysed but can also be driven non-
Shin Yee Hong, Li Theng Ng, Li Fang Ng, Takao Inoue, Nicholas S Tolwinski, Thilo Hagen, Jan Gruber   +6 more
doaj   +2 more sources

Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling [PDF]

Open Biology, 2021
The acylated peptide hormone ghrelin impacts a wide range of physiological processes but is most well known for controlling hunger and metabolic regulation.
Tasha R. Davis, Mariah R. Pierce, Sadie X. Novak, James L. Hougland   +3 more
doaj   +2 more sources

Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors [PDF]

Cell Communication and Signaling
Acylation modification plays a crucial role in tumor progression through altering protein homeostasis and localization. However, a comprehensive summary of these processes is lacking.
Jialin Jiang, Jiabin Chen, Shuhang Huang, Yue Tian, Lanyu Liu, Jiahui Yao, Yuzhu Zhang, Can Jiang, Xingting Zhang, Na Han, Guang Shu, Gang Yin, Li Xian Yip, Kuoran Xing, David Tai Leong, Maonan Wang   +15 more
doaj   +2 more sources

Factors Affecting Non-Enzymatic Protein Acylation by trans-3-Methylglutaconyl Coenzyme A [PDF]

Metabolites
The leucine catabolism pathway intermediate, trans-3-methylglutaconyl (3MGC) CoA, is considered to be the precursor of 3MGC acid, a urinary organic acid associated with specific inborn errors of metabolism (IEM).
Elizabeth A. Jennings, Megan M. Macdonald, Irina Romenskaia, Hao Yang, Grant A. Mitchell, Robert O. Ryan   +5 more
doaj   +2 more sources

Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [PDF]

Autophagy Reports
Protein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
doaj   +2 more sources

Acylation modification-mediated metabolism reprogramming in cancer [PDF]

iScience
Summary: With the development of high-resolution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), various modifications resulting from the reactivity of acyl-CoA intermediates with protein residues have been identified.
Kaiwei Huang, Yunshan Wang, Bohao Li, Yuchen Xiu, Hanxiang Zhan, Guangwei Wei, Yangmiao Duan   +6 more
doaj   +2 more sources