Results 131 to 140 of about 32,649 (220)
Straight A's: protein acylation in the S-activation and autophagic degradation of NOD-like receptors. [PDF]
Biochem Soc TransMartin NR, Fairn GD.
europepmc +1 more source
Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product
Protein Science, Volume 35, Issue 3, March 2026.Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo +5 more
wiley +1 more source
Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides
Journal of Peptide Science, Volume 32, Issue 3, March 2026.As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama +2 more
wiley +1 more source
A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation. [PDF]
Cell Metab, 2017 Wagner GR +11 more
europepmc +1 more source
Sustainable Food Proteins, Volume 4, Issue 1, March 2026.The lacking essential amino acids, low digestibility, bioavailability, bitterness, and presence of anti‐nutritional factors that limit the consumption of plant proteins and their use in food formulations are discussed comprehensively. The findings of recent studies on novel technologies and computer‐based applications used to cope with these challenges
Humeyra Cavdar Dincturk +3 more
wiley +1 more source
Small, Volume 22, Issue 16, 17 March 2026.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Small Science, Volume 6, Issue 3, March 2026.This work demonstrates a unique eukaryotic Argonaute nuclease, TtpAgo, from Thermochaetoides thermophila DSM 1495 that can be programmed with either DNA or RNA guides and can cleave both DNA and RNA targets at mesophilic temperatures in vitro. TtpAgo binds 12–30 nt long 5′P or 5′OH guide molecules without strict sequence specificity, thus provides a ...
Zhizhao Chen +4 more
wiley +1 more source
The Chemical Record, Volume 26, Issue 3, March 2026.This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim +4 more
wiley +1 more source
Design, Synthesis, and Evaluation of Bis‐Chalcones and Bis‐Flavones as Selective COX‐2 Inhibitors
Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.Novel bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition and the ability to inhibit PGE2 production in whole human blood. Notably, a monomeric chalcone with a similar substitution pattern exhibited even greater activity, providing valuable insights to guide the future design and optimization of flavonoid‐based COX‐2
Rui Pereira +4 more
wiley +1 more source